Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 09:33, 8 November 2007 (UTC)[edit]
Proteins without matches (22)[edit]
Proteins with a High Potential Match (3)[edit]
Created (11)[edit]
Manual Inspection (Page not found) (14)[edit]
Protein Status Grid - Date: 09:33, 8 November 2007 (UTC)[edit]
Vebose Log - Date: 09:33, 8 November 2007 (UTC)[edit]
- INFO: Beginning work on ALOX12... {November 8, 2007 1:02:54 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:03:27 AM PST}
- CREATED: Created new protein page: ALOX12 {November 8, 2007 1:03:34 AM PST}
- INFO: Beginning work on ATP8... {November 8, 2007 1:16:51 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:17:08 AM PST}
- CREATED: Created new protein page: ATP8 {November 8, 2007 1:17:16 AM PST}
- INFO: Beginning work on CBX5... {November 8, 2007 1:24:47 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:25:31 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chromobox homolog 5 (HP1 alpha homolog, Drosophila)
| HGNCid = 1555
| Symbol = CBX5
| AltSymbols =; HP1; HP1-ALPHA; HP1Hs-alpha
| OMIM = 604478
| ECnumber =
| Homologene = 7257
| MGIid = 109372
| GeneAtlas_image1 = PBB_GE_CBX5_209715_at_tn.png
| Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000776 |text = kinetochore}} {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005720 |text = nuclear heterochromatin}}
| Process = {{GNF_GO|id=GO:0006333 |text = chromatin assembly or disassembly}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 23468
| Hs_Ensembl = ENSG00000094916
| Hs_RefseqProtein = NP_036249
| Hs_RefseqmRNA = NM_012117
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 52921003
| Hs_GenLoc_end = 52960153
| Hs_Uniprot = P45973
| Mm_EntrezGene = 12419
| Mm_Ensembl = ENSMUSG00000009575
| Mm_RefseqmRNA = XM_001000807
| Mm_RefseqProtein = XP_001000807
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 103024721
| Mm_GenLoc_end = 103067850
| Mm_Uniprot = Q61686
}}
}}
'''Chromobox homolog 5 (HP1 alpha homolog, Drosophila)''', also known as '''CBX5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CBX5 chromobox homolog 5 (HP1 alpha homolog, Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23468| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CDC20... {November 8, 2007 1:03:34 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:04:12 AM PST}
- CREATED: Created new protein page: CDC20 {November 8, 2007 1:04:19 AM PST}
- INFO: Beginning work on COL4A4... {November 8, 2007 1:04:19 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:04:51 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type IV, alpha 4
| HGNCid = 2206
| Symbol = COL4A4
| AltSymbols =; CA44
| OMIM = 120131
| ECnumber =
| Homologene = 20071
| MGIid = 104687
| GeneAtlas_image1 = PBB_GE_COL4A4_214602_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005587 |text = collagen type IV}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0042062 |text = long-term strengthening of neuromuscular junction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1286
| Hs_Ensembl = ENSG00000081052
| Hs_RefseqProtein = NP_000083
| Hs_RefseqmRNA = NM_000092
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 227578177
| Hs_GenLoc_end = 227737519
| Hs_Uniprot = P53420
| Mm_EntrezGene = 12829
| Mm_Ensembl = ENSMUSG00000067158
| Mm_RefseqmRNA = NM_007735
| Mm_RefseqProtein = NP_031761
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 82331582
| Mm_GenLoc_end = 82465816
| Mm_Uniprot =
}}
}}
'''Collagen, type IV, alpha 4''', also known as '''COL4A4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR.<ref>{{cite web | title = Entrez Gene: COL4A4 collagen, type IV, alpha 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1286| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hinek A |title=Nature and the multiple functions of the 67-kD elastin-/laminin binding protein. |journal=Cell Adhes. Commun. |volume=2 |issue= 3 |pages= 185-93 |year= 1995 |pmid= 7827955 |doi= }}
*{{cite journal | author=Hudson BG, Reeders ST, Tryggvason K |title=Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26033-6 |year= 1994 |pmid= 8253711 |doi= }}
*{{cite journal | author=Lemmink HH, Schröder CH, Monnens LA, Smeets HJ |title=The clinical spectrum of type IV collagen mutations. |journal=Hum. Mutat. |volume=9 |issue= 6 |pages= 477-99 |year= 1997 |pmid= 9195222 |doi= 10.1002/(SICI)1098-1004(1997)9:6<477::AID-HUMU1>3.0.CO;2-# }}
*{{cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221-7 |year= 1999 |pmid= 10382266 |doi= }}
*{{cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146-59 |year= 1999 |pmid= 10416788 |doi= }}
*{{cite journal | author=Pescucci C, Longo I, Bruttini M, ''et al.'' |title=Type-IV collagen related diseases. |journal=J. Nephrol. |volume=16 |issue= 2 |pages= 314-6 |year= 2003 |pmid= 12768082 |doi= }}
*{{cite journal | author=Torra R, Tazón-Vega B, Ars E, Ballarín J |title=Collagen type IV (alpha3-alpha4) nephropathy: from isolated haematuria to renal failure. |journal=Nephrol. Dial. Transplant. |volume=19 |issue= 10 |pages= 2429-32 |year= 2005 |pmid= 15280517 |doi= 10.1093/ndt/gfh435 }}
*{{cite journal | author=Rana K, Wang YY, Buzza M, ''et al.'' |title=The genetics of thin basement membrane nephropathy. |journal=Semin. Nephrol. |volume=25 |issue= 3 |pages= 163-70 |year= 2005 |pmid= 15880327 |doi= }}
*{{cite journal | author=Maziers N, Dahan K, Pirson Y |title=[From Alport syndrome to benign familial hematuria: clinical and genetic aspect] |journal=Nephrol. Ther. |volume=1 |issue= 2 |pages= 90-100 |year= 2006 |pmid= 16895672 |doi= 10.1016/j.nephro.2005.03.005 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DPYD... {November 8, 2007 1:04:51 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DPYD image.jpg {November 8, 2007 1:05:27 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:05:44 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DPYD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gt8.
| PDB = {{PDB2|1gt8}}, {{PDB2|1gte}}, {{PDB2|1gth}}, {{PDB2|1h7w}}, {{PDB2|1h7x}}
| Name = Dihydropyrimidine dehydrogenase
| HGNCid = 3012
| Symbol = DPYD
| AltSymbols =; DHP; DPD; MGC132008; MGC70799
| OMIM = 274270
| ECnumber =
| Homologene = 85
| MGIid = 2139667
| GeneAtlas_image1 = PBB_GE_DPYD_204646_at_tn.png
| Function = {{GNF_GO|id=GO:0004152 |text = dihydroorotate dehydrogenase activity}} {{GNF_GO|id=GO:0004158 |text = dihydroorotate oxidase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0015036 |text = disulfide oxidoreductase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0017113 |text = dihydropyrimidine dehydrogenase (NADP+) activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0051539 |text = 4 iron, 4 sulfur cluster binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006207 |text = 'de novo' pyrimidine base biosynthetic process}} {{GNF_GO|id=GO:0006212 |text = uracil catabolic process}} {{GNF_GO|id=GO:0006214 |text = thymidine catabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1806
| Hs_Ensembl = ENSG00000188641
| Hs_RefseqProtein = NP_000101
| Hs_RefseqmRNA = NM_000110
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 97315887
| Hs_GenLoc_end = 98159193
| Hs_Uniprot = Q12882
| Mm_EntrezGene = 99586
| Mm_Ensembl = ENSMUSG00000033308
| Mm_RefseqmRNA = NM_170778
| Mm_RefseqProtein = NP_740748
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 118554180
| Mm_GenLoc_end = 119424922
| Mm_Uniprot =
}}
}}
'''Dihydropyrimidine dehydrogenase''', also known as '''DPYD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Genetic deficiency of this enzyme results in an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy.<ref>{{cite web | title = Entrez Gene: DPYD dihydropyrimidine dehydrogenase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1806| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hoff PM, Royce M, Medgyesy D, ''et al.'' |title=Oral fluoropoyrimidines. |journal=Semin. Oncol. |volume=26 |issue= 6 |pages= 640-6 |year= 1999 |pmid= 10606257 |doi= }}
*{{cite journal | author=Schneider HB, Becker H |title=Impact of dihydropyrimidine dehydrogenase on 5-fluorouracil treatment in cancer patients. |journal=Eur. J. Med. Res. |volume=8 |issue= 5 |pages= 226-8 |year= 2004 |pmid= 12844478 |doi= }}
*{{cite journal | author=Omura K |title=Clinical implications of dihydropyrimidine dehydrogenase (DPD) activity in 5-FU-based chemotherapy: mutations in the DPD gene, and DPD inhibitory fluoropyrimidines. |journal=Int. J. Clin. Oncol. |volume=8 |issue= 3 |pages= 132-8 |year= 2003 |pmid= 12851836 |doi= 10.1007/s10147-003-0330-z }}
*{{cite journal | author=Lee W, Lockhart AC, Kim RB, Rothenberg ML |title=Cancer pharmacogenomics: powerful tools in cancer chemotherapy and drug development. |journal=Oncologist |volume=10 |issue= 2 |pages= 104-11 |year= 2005 |pmid= 15709212 |doi= 10.1634/theoncologist.10-2-104 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FLT4... {November 8, 2007 1:05:44 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:06:05 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Fms-related tyrosine kinase 4
| HGNCid = 3767
| Symbol = FLT4
| AltSymbols =; FLT41; PCL; VEGFR3
| OMIM = 136352
| ECnumber =
| Homologene = 7321
| MGIid = 95561
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005021 |text = vascular endothelial growth factor receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2324
| Hs_Ensembl = ENSG00000037280
| Hs_RefseqProtein = NP_002011
| Hs_RefseqmRNA = NM_002020
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 179962143
| Hs_GenLoc_end = 180009171
| Hs_Uniprot = P35916
| Mm_EntrezGene = 14257
| Mm_Ensembl = ENSMUSG00000020357
| Mm_RefseqmRNA = NM_008029
| Mm_RefseqProtein = NP_032055
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 49453150
| Mm_GenLoc_end = 49495652
| Mm_Uniprot = Q5SU94
}}
}}
'''Fms-related tyrosine kinase 4''', also known as '''FLT4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Petrova TV, Makinen T, Alitalo K |title=Signaling via vascular endothelial growth factor receptors. |journal=Exp. Cell Res. |volume=253 |issue= 1 |pages= 117-30 |year= 1999 |pmid= 10579917 |doi= 10.1006/excr.1999.4707 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GLI1... {November 8, 2007 1:06:05 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GLI1 image.jpg {November 8, 2007 1:06:39 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:06:49 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GLI1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2gli.
| PDB = {{PDB2|2gli}}
| Name = Glioma-associated oncogene homolog 1 (zinc finger protein)
| HGNCid = 4317
| Symbol = GLI1
| AltSymbols =; GLI
| OMIM = 165220
| ECnumber =
| Homologene = 3859
| MGIid = 95727
| GeneAtlas_image1 = PBB_GE_GLI1_206646_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008017 |text = microtubule binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0008589 |text = regulation of smoothened signaling pathway}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2735
| Hs_Ensembl = ENSG00000111087
| Hs_RefseqProtein = NP_005260
| Hs_RefseqmRNA = NM_005269
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 56140201
| Hs_GenLoc_end = 56152312
| Hs_Uniprot = P08151
| Mm_EntrezGene = 14632
| Mm_Ensembl = ENSMUSG00000025407
| Mm_RefseqmRNA = XM_989852
| Mm_RefseqProtein = XP_994946
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 126732838
| Mm_GenLoc_end = 126744538
| Mm_Uniprot = P47806
}}
}}
'''Glioma-associated oncogene homolog 1 (zinc finger protein)''', also known as '''GLI1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein which is a member of the Kruppel family of zinc finger proteins. The function of this gene has not been determined; however, it may play a role in normal development gene transcription. Mouse mutation studies indicate possible involvement in human foregut malformation.<ref>{{cite web | title = Entrez Gene: GLI1 glioma-associated oncogene homolog 1 (zinc finger protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2735| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Chung RY, Seizinger BR |title=Molecular genetics of neurological tumours. |journal=J. Med. Genet. |volume=29 |issue= 6 |pages= 361-7 |year= 1992 |pmid= 1320124 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HNRPD... {November 8, 2007 1:06:49 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HNRPD image.jpg {November 8, 2007 1:09:18 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:09:35 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HNRPD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hd0.
| PDB = {{PDB2|1hd0}}, {{PDB2|1hd1}}, {{PDB2|1iqt}}, {{PDB2|1wtb}}, {{PDB2|1x0f}}
| Name = Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
| HGNCid = 5036
| Symbol = HNRPD
| AltSymbols =; AUF1; AUF1A; P37; hnRNPD0
| OMIM = 601324
| ECnumber =
| Homologene = 22410
| MGIid =
| GeneAtlas_image1 = PBB_GE_HNRPD_209330_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HNRPD_221480_at_tn.png
| GeneAtlas_image3 = PBB_GE_HNRPD_221481_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003729 |text = mRNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}}
| Component = {{GNF_GO|id=GO:0000781 |text = chromosome, telomeric region}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006396 |text = RNA processing}} {{GNF_GO|id=GO:0006401 |text = RNA catabolic process}} {{GNF_GO|id=GO:0006402 |text = mRNA catabolic process}} {{GNF_GO|id=GO:0043488 |text = regulation of mRNA stability}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3184
| Hs_Ensembl = ENSG00000138668
| Hs_RefseqProtein = NP_001003810
| Hs_RefseqmRNA = NM_001003810
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 83493491
| Hs_GenLoc_end = 83514173
| Hs_Uniprot = Q14103
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)''', also known as '''HNRPD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.<ref>{{cite web | title = Entrez Gene: HNRPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3184| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HOXA10... {November 8, 2007 1:09:35 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:10:34 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Homeobox A10
| HGNCid = 5100
| Symbol = HOXA10
| AltSymbols =; PL; HOX1; HOX1.8; HOX1H; MGC12859
| OMIM = 142957
| ECnumber =
| Homologene = 7365
| MGIid = 96171
| GeneAtlas_image1 = PBB_GE_HOXA10_213150_at_tn.png
| GeneAtlas_image2 = PBB_GE_HOXA10_213147_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3206
| Hs_Ensembl = ENSG00000153807
| Hs_RefseqProtein = NP_061824
| Hs_RefseqmRNA = NM_018951
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 27177382
| Hs_GenLoc_end = 27180399
| Hs_Uniprot = P31260
| Mm_EntrezGene = 15395
| Mm_Ensembl = ENSMUSG00000000938
| Mm_RefseqmRNA = NM_008263
| Mm_RefseqProtein = NP_032289
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 52160780
| Mm_GenLoc_end = 52164522
| Mm_Uniprot = P31310
}}
}}
'''Homeobox A10''', also known as '''HOXA10''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.<ref>{{cite web | title = Entrez Gene: HOXA10 homeobox A10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3206| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Eun Kwon H, Taylor HS |title=The role of HOX genes in human implantation. |journal=Ann. N. Y. Acad. Sci. |volume=1034 |issue= |pages= 1-18 |year= 2005 |pmid= 15731295 |doi= 10.1196/annals.1335.001 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IGFBP4... {November 8, 2007 1:10:34 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IGFBP4 image.jpg {November 8, 2007 1:11:09 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:11:26 AM PST}
- CREATED: Created new protein page: IGFBP4 {November 8, 2007 1:11:33 AM PST}
- INFO: Beginning work on INSL3... {November 8, 2007 1:11:33 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein INSL3 image.jpg {November 8, 2007 1:11:47 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:12:03 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_INSL3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2h8b.
| PDB = {{PDB2|2h8b}}
| Name = Insulin-like 3 (Leydig cell)
| HGNCid = 6086
| Symbol = INSL3
| AltSymbols =; MGC119818; MGC119819; RLF; RLNL
| OMIM = 146738
| ECnumber =
| Homologene = 4048
| MGIid = 108427
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005158 |text = insulin receptor binding}} {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3640
| Hs_Ensembl =
| Hs_RefseqProtein = NP_005534
| Hs_RefseqmRNA = NM_005543
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 16336
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_013564
| Mm_RefseqProtein = NP_038592
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Insulin-like 3 (Leydig cell)''', also known as '''INSL3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is an insulin like hormone produced mainly in gonadal tissues in males and females. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. It may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. The mutations in this gene may lead to, but not a frequent cause of, cryptorchidism.<ref>{{cite web | title = Entrez Gene: INSL3 insulin-like 3 (Leydig cell)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3640| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on JUND... {November 8, 2007 1:12:03 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:13:10 AM PST}
- CREATED: Created new protein page: JUND {November 8, 2007 1:13:17 AM PST}
- INFO: Beginning work on KLK1... {November 8, 2007 1:13:17 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein KLK1 image.jpg {November 8, 2007 1:13:49 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:14:02 AM PST}
- CREATED: Created new protein page: KLK1 {November 8, 2007 1:14:08 AM PST}
- INFO: Beginning work on MCM2... {November 8, 2007 1:16:02 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:16:44 AM PST}
- CREATED: Created new protein page: MCM2 {November 8, 2007 1:16:51 AM PST}
- INFO: Beginning work on NCSTN... {November 8, 2007 1:24:14 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:24:47 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nicastrin
| HGNCid = 17091
| Symbol = NCSTN
| AltSymbols =; APH2; KIAA0253; RP11-517F10.1
| OMIM = 605254
| ECnumber =
| Homologene = 41029
| MGIid = 1891700
| GeneAtlas_image1 = PBB_GE_NCSTN_208759_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006509 |text = membrane protein ectodomain proteolysis}} {{GNF_GO|id=GO:0007220 |text = Notch receptor processing}} {{GNF_GO|id=GO:0016485 |text = protein processing}} {{GNF_GO|id=GO:0042987 |text = amyloid precursor protein catabolic process}} {{GNF_GO|id=GO:0043085 |text = positive regulation of enzyme activity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 23385
| Hs_Ensembl = ENSG00000162736
| Hs_RefseqProtein = NP_056146
| Hs_RefseqmRNA = NM_015331
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 158579678
| Hs_GenLoc_end = 158595366
| Hs_Uniprot = Q92542
| Mm_EntrezGene = 59287
| Mm_Ensembl = ENSMUSG00000003458
| Mm_RefseqmRNA = NM_021607
| Mm_RefseqProtein = NP_067620
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 173902696
| Mm_GenLoc_end = 173919424
| Mm_Uniprot = Q3T9E5
}}
}}
'''Nicastrin''', also known as '''NCSTN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.<ref>{{cite web | title = Entrez Gene: NCSTN nicastrin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23385| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PROCR... {November 8, 2007 1:23:18 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PROCR image.jpg {November 8, 2007 1:23:51 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:24:14 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PROCR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1l8j.
| PDB = {{PDB2|1l8j}}, {{PDB2|1lqv}}
| Name = Protein C receptor, endothelial (EPCR)
| HGNCid = 9452
| Symbol = PROCR
| AltSymbols =; CCCA; CCD41; CD201; EPCR; MGC23024; bA42O4.2
| OMIM = 600646
| ECnumber =
| Homologene = 4670
| MGIid = 104596
| GeneAtlas_image1 = PBB_GE_PROCR_203650_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005813 |text = centrosome}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10544
| Hs_Ensembl = ENSG00000101000
| Hs_RefseqProtein = NP_006395
| Hs_RefseqmRNA = NM_006404
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 33212131
| Hs_GenLoc_end = 33228826
| Hs_Uniprot = Q9UNN8
| Mm_EntrezGene = 19124
| Mm_Ensembl = ENSMUSG00000027611
| Mm_RefseqmRNA = NM_011171
| Mm_RefseqProtein = NP_035301
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 155442784
| Mm_GenLoc_end = 155446899
| Mm_Uniprot = Q4FK76
}}
}}
'''Protein C receptor, endothelial (EPCR)''', also known as '''PROCR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.<ref>{{cite web | title = Entrez Gene: PROCR protein C receptor, endothelial (EPCR)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10544| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Esmon CT |title=Coagulation and inflammation. |journal=J. Endotoxin Res. |volume=9 |issue= 3 |pages= 192-8 |year= 2004 |pmid= 12831462 |doi= 10.1179/096805103125001603 }}
*{{cite journal | author=Ruf W, Dorfleutner A, Riewald M |title=Specificity of coagulation factor signaling. |journal=J. Thromb. Haemost. |volume=1 |issue= 7 |pages= 1495-503 |year= 2003 |pmid= 12871285 |doi= }}
*{{cite journal | author=Van de Wouwer M, Collen D, Conway EM |title=Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 8 |pages= 1374-83 |year= 2005 |pmid= 15178554 |doi= 10.1161/01.ATV.0000134298.25489.92 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSMC2... {November 8, 2007 1:17:16 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:18:15 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) 26S subunit, ATPase, 2
| HGNCid = 9548
| Symbol = PSMC2
| AltSymbols =; S7; MGC3004; MSS1; Nbla10058
| OMIM = 154365
| ECnumber =
| Homologene = 2096
| MGIid = 109555
| GeneAtlas_image1 = PBB_GE_PSMC2_201068_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PSMC2_201067_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0017111 |text = nucleoside-triphosphatase activity}}
| Component = {{GNF_GO|id=GO:0000502 |text = proteasome complex (sensu Eukaryota)}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0030163 |text = protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5701
| Hs_Ensembl = ENSG00000161057
| Hs_RefseqProtein = NP_002794
| Hs_RefseqmRNA = NM_002803
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 102775325
| Hs_GenLoc_end = 102795891
| Hs_Uniprot = P35998
| Mm_EntrezGene = 19181
| Mm_Ensembl = ENSMUSG00000028932
| Mm_RefseqmRNA = NM_011188
| Mm_RefseqProtein = NP_035318
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 21297107
| Mm_GenLoc_end = 21315608
| Mm_Uniprot = Q3U5V3
}}
}}
'''Proteasome (prosome, macropain) 26S subunit, ATPase, 2''', also known as '''PSMC2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex.<ref>{{cite web | title = Entrez Gene: PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5701| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSMC3... {November 8, 2007 1:18:15 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:18:48 AM PST}
- CREATED: Created new protein page: PSMC3 {November 8, 2007 1:18:55 AM PST}
- INFO: Beginning work on PTPN12... {November 8, 2007 1:18:55 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:19:46 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Protein tyrosine phosphatase, non-receptor type 12
| HGNCid = 9645
| Symbol = PTPN12
| AltSymbols =; PTP-PEST; PTPG1
| OMIM = 600079
| ECnumber =
| Homologene = 37691
| MGIid = 104673
| GeneAtlas_image1 = PBB_GE_PTPN12_202006_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTPN12_216915_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004726 |text = non-membrane spanning protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0017124 |text = SH3 domain binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5782
| Hs_Ensembl = ENSG00000127947
| Hs_RefseqProtein = NP_002826
| Hs_RefseqmRNA = NM_002835
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 77004351
| Hs_GenLoc_end = 77107324
| Hs_Uniprot = Q05209
| Mm_EntrezGene = 19248
| Mm_Ensembl = ENSMUSG00000028771
| Mm_RefseqmRNA = NM_011203
| Mm_RefseqProtein = NP_035333
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 20498465
| Mm_GenLoc_end = 20567621
| Mm_Uniprot = Q3TVC3
}}
}}
'''Protein tyrosine phosphatase, non-receptor type 12''', also known as '''PTPN12''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.<ref>{{cite web | title = Entrez Gene: PTPN12 protein tyrosine phosphatase, non-receptor type 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5782| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RAB7A... {November 8, 2007 1:21:14 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RAB7A image.jpg {November 8, 2007 1:21:42 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:21:57 AM PST}
- CREATED: Created new protein page: RAB7A {November 8, 2007 1:22:04 AM PST}
- INFO: Beginning work on TFPI2... {November 8, 2007 1:22:04 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TFPI2 image.jpg {November 8, 2007 1:22:56 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:23:11 AM PST}
- CREATED: Created new protein page: TFPI2 {November 8, 2007 1:23:18 AM PST}
- INFO: Beginning work on TNPO1... {November 8, 2007 1:14:08 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TNPO1 image.jpg {November 8, 2007 1:15:43 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:16:02 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TNPO1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qbk.
| PDB = {{PDB2|1qbk}}, {{PDB2|2h4m}}, {{PDB2|2ot8}}
| Name = Transportin 1
| HGNCid = 6401
| Symbol = TNPO1
| AltSymbols =; IPO2; KPNB2; MIP; MIP1; TRN
| OMIM = 602901
| ECnumber =
| Homologene = 5358
| MGIid = 2681523
| GeneAtlas_image1 = PBB_GE_TNPO1_221829_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TNPO1_207657_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_TNPO1_209225_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008139 |text = nuclear localization sequence binding}} {{GNF_GO|id=GO:0008565 |text = protein transporter activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005643 |text = nuclear pore}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000059 |text = protein import into nucleus, docking}} {{GNF_GO|id=GO:0000060 |text = protein import into nucleus, translocation}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3842
| Hs_Ensembl = ENSG00000083312
| Hs_RefseqProtein = NP_002261
| Hs_RefseqmRNA = NM_002270
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 72148171
| Hs_GenLoc_end = 72248316
| Hs_Uniprot = Q92973
| Mm_EntrezGene = 238799
| Mm_Ensembl = ENSMUSG00000009470
| Mm_RefseqmRNA = NM_001048267
| Mm_RefseqProtein = NP_001041732
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 99942895
| Mm_GenLoc_end = 100026541
| Mm_Uniprot = Q3TKD0
}}
}}
'''Transportin 1''', also known as '''TNPO1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins.<ref>{{cite web | title = Entrez Gene: TNPO1 transportin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3842| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: in search of a leader. |journal=Front. Biosci. |volume=2 |issue= |pages= d578-87 |year= 2004 |pmid= 9366553 |doi= }}
*{{cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. |journal=Mol. Med. |volume=4 |issue= 3 |pages= 138-43 |year= 1998 |pmid= 9562972 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TOP2B... {November 8, 2007 1:19:46 AM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:20:18 AM PST}
- CREATED: Created new protein page: TOP2B {November 8, 2007 1:20:25 AM PST}
- INFO: Beginning work on TPH1... {November 8, 2007 1:20:25 AM PST}
- UPLOAD: Added new Image to wiki:
{November 8, 2007 1:21:00 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:21:14 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TPH1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mlw.
| PDB = {{PDB2|1mlw}}
| Name = Tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)
| HGNCid = 12008
| Symbol = TPH1
| AltSymbols =; MGC119994; TPH; TPRH
| OMIM = 191060
| ECnumber =
| Homologene = 3080
| MGIid = 98796
| GeneAtlas_image1 = PBB_GE_TPH1_214601_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0004510 |text = tryptophan 5-monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0016597 |text = amino acid binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006587 |text = serotonin biosynthetic process from tryptophan}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0009072 |text = aromatic amino acid family metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7166
| Hs_Ensembl = ENSG00000129167
| Hs_RefseqProtein = NP_004170
| Hs_RefseqmRNA = NM_004179
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 17997772
| Hs_GenLoc_end = 18018885
| Hs_Uniprot = P17752
| Mm_EntrezGene = 21990
| Mm_Ensembl = ENSMUSG00000040046
| Mm_RefseqmRNA = NM_009414
| Mm_RefseqProtein = NP_033440
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 46515203
| Mm_GenLoc_end = 46540579
| Mm_Uniprot = Q3UK52
}}
}}
'''Tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)''', also known as '''TPH1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Tryptophan hydroxylase (TPH; EC 1.14.16.4) catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. It is thus the rate-limiting enzyme in the biosynthesis of serotonin. TPH expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: TPH1 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7166| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Li D, He L |title=Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses. |journal=Hum. Genet. |volume=119 |issue= 3 |pages= 233-40 |year= 2007 |pmid= 16450114 |doi= 10.1007/s00439-005-0113-x }}
}}
{{refend}}
{{protein-stub}}
end log.
