User:Mr. Ibrahem/Zolmitriptan
Clinical data | |
---|---|
Trade names | Zomig, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601129 |
License data |
|
Pregnancy category |
|
Routes of administration | By mouth, nasal spray |
Drug class | Triptan[2] |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | 40% (by mouth) |
Protein binding | 25% |
Metabolism | Liver (CYP1A2-mediated, to active metabolite) |
Elimination half-life | 3 hours |
Excretion | Kidney (65%) and fecal (35%) |
Identifiers | |
| |
Chemical and physical data | |
Formula | C16H21N3O2 |
Molar mass | 287.363 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Zolmitriptan, sold under the brand name Zomig among others, is a medication used to treat migraine attacks and cluster headaches.[3] It may also be used to prevent menstrual migraines.[3] It is used as a tablet by mouth or as a nose spray.[3]
Common side effects include tingling, nausea, dry mouth, and dizziness.[2] Other side effects may include medication overuse headaches.[2] Serious side effects may include coronary vasospasm, stroke, high blood pressure, anaphylaxis, and serotonin syndrome.[2] It is unclear if use during pregnancy or breastfeeding is safe.[1][3] It is a triptan that works as a selective serotonin receptor agonist of the 1B and 1D subtypes.[2]
Zolmitriptan was patented in 1990 and approved for medical use in 1997.[4] It is avaliable as a generic medication.[3] In the United Kingdom 6 doses costs the NHS about £12 as of 2020.[3] This amount in the United States costs about 30 USD as of 2021.[5]
References[edit]
- ^ a b c "Zolmitriptan Use During Pregnancy". Drugs.com. Archived from the original on 26 November 2020. Retrieved 4 August 2021.
- ^ a b c d e f g "Zolmitriptan Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2020. Retrieved 3 August 2021.
- ^ a b c d e f g h BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 504. ISBN 978-0-85711-369-6.
{{cite book}}
: CS1 maint: date format (link) - ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 531. ISBN 9783527607495. Archived from the original on 2020-10-23. Retrieved 2021-01-20.
- ^ "Zolmitriptan Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 3 August 2021.