User:Mr. Ibrahem/Trimipramine

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Mr. Ibrahem/Trimipramine
Clinical data
Trade namesSurmontil, others
Other namesTrimeproprimine; IF-6120; IL-6001; RP-7162; 2'-Methylimipramine; β-Methylimipramine
AHFS/Drugs.com
MedlinePlusa602010
License data
Pregnancy
category
  • AU: C
Routes of
administration		By mouth, intramuscular injection, intravenous
Drug classTricyclic antidepressant (TCA)[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability41%[2][3][4][5]
Protein binding94.9%[2][3][4][5]
MetabolismLiver[2][3][4][5]
Elimination half-life23–24 hours[2][3][4][5]
ExcretionKidney[2][3][4][5]
Identifiers
  • (±)-3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine
Chemical and physical data
FormulaC20H26N2
Molar mass294.442 g·mol−1
3D model (JSmol)
  • c1cc3c(cc1)CCc2c(cccc2)N3CC(C)CN(C)C
  • InChI=1S/C20H26N2/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22/h4-11,16H,12-15H2,1-3H3 checkY
  • Key:ZSCDBOWYZJWBIY-UHFFFAOYSA-N checkY
  (verify)

Trimipramine, sold under the brand name Surmontil among others, is a medication primarily used to treat major depressive disorder.[1] Other uses may include trouble sleeping and bedwetting in children.[1] It is taken by mouth.[1] Benefits may required more than two weeks to occur.[1]

Common side effects include sleepiness, dry mouth, constipation, low blood pressure with standing, and increased weight.[1] Other side effects may include high blood sugar, liver problems, suicide, and sexual dysfunction.[6] It is a tricyclic antidepressant (TCA); however, how it works is not entirely clear.[1]

was approved for medical use in the United States in 1979.[1] It is available as a generic medication.[6] In the United Kingdom 28 tablets of 50 mg costs the NHS about 220 pounds as of 2021.[6] This amount in the United States costs about 50 USD.[7]

References[edit]

  1. ^ a b c d e f g h i j "Trimipramine Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 20 September 2021.
  2. ^ a b c d e "PRODUCT INFORMATION SURMONTIL® Tablets and Capsules" (PDF). TGA eBusiness Services. Aspen Pharmacare Australia Pty Ltd. 28 November 2012. Archived from the original on 1 November 2016. Retrieved 30 November 2013.
  3. ^ a b c d e "SURMONTIL (trimipramine maleate) capsule [Duramed Pharmaceuticals Inc]". DailyMed. Duramed Pharmaceuticals Inc. December 2012. Archived from the original on 4 July 2013. Retrieved 30 November 2013.
  4. ^ a b c d e "Surmontil, Trimip (trimipramine) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 3 December 2013. Retrieved 30 November 2013.
  5. ^ a b c d e "Trimipramine 50mg Capsules - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Zentiva. 19 November 2012. Archived from the original on 3 December 2013. Retrieved 30 November 2013.
  6. ^ a b c d BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 396. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
  7. ^ "Trimipramine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 June 2016. Retrieved 20 September 2021.
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