User:Mr. Ibrahem/Triamterene
 | |
 | |
| Clinical data | |
|---|---|
| Trade names | Dyrenium, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682337 |
| Pregnancy category |
|
| Routes of administration | By mouth |
| Drug class | Potassium-sparing diuretic[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 30-70% |
| Protein binding | 67% |
| Metabolism | hydroxylation to para-hydroxytriamterene |
| Elimination half-life | 1-2 hours, active metabolite 3 hours |
| Excretion | renal <50%, 21% unchanged |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C12H11N7 |
| Molar mass | 253.269 g·mol−1 |
| |
  (what is this?) (verify) | |
Triamterene, sold under the brand name Dyrenium among others, is a medication used to treat heart failure, high blood pressure, or swelling.[1] For high blood pressure it is generally used together with other medication.[1] It is taken by mouth.[1] Maximal effects may take a few days.[1]
Common side effects include high potassium, kidney problems, liver problems, nausea, weakness, and low platelets.[1] Urine may also appear blue tinged.[2] Great care is required in those with diabetes, older people, and those with gout.[2] While use is not generally recommended in pregnancy, there is no clear evidence of harm.[3] It is a potassium-sparing diuretic.[1]
Triamterene was approved for medical use in the United States in 1964.[1] It is avaliable as a generic medication.[4] In the United Kingdom a month costs the NHS about 42 pounds at a dose of 50 mg per day as of 2021.[4] This amount in the United States costs about 250 USD.[5] It is available in combination as hydrochlorothiazide/triamterene, chlortalidone/triamterene, and furosemide/triamterene.[2]
References[edit]
- ^ a b c d e f g h i j "Triamterene Monograph for Professionals". Drugs.com. Archived from the original on 17 January 2017. Retrieved 17 September 2021.
- ^ a b c BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 244. ISBN 978-0-85711-369-6.
{{cite book}}: CS1 maint: date format (link) - ^ "Triamterene (Dyrenium) Use During Pregnancy". Drugs.com. Archived from the original on 31 October 2020. Retrieved 17 September 2021.
- ^ a b Cite error: The named reference
BNF2021was invoked but never defined (see the help page). - ^ "Triamterene Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 17 September 2021.