User:Mr. Ibrahem/Topiramate

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Mr. Ibrahem/Topiramate
Clinical data
Trade namesTopamax, Trokendi XR, Qudexy XR, others
Other namesTopiramic acid
AHFS/Drugs.comMonograph
MedlinePlusa697012
License data
Pregnancy
category
  • AU: D
Routes of
administration		By mouth
Legal status
Legal status
Pharmacokinetic data
Bioavailability80%
Protein binding13–17%; 15–41%
MetabolismLiver (20–30%)
Elimination half-life19–25 hours
ExcretionUrine (70–80%)
Identifiers
  • 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
Chemical and physical data
FormulaC12H21NO8S
Molar mass339.36 g·mol−1
3D model (JSmol)
  • O=S(=O)(OC[C@@]21OC(O[C@H]1[C@@H]3OC(O[C@@H]3CO2)(C)C)(C)C)N
  • InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 checkY
  • Key:KJADKKWYZYXHBB-XBWDGYHZSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Topiramate, sold under the brand name Topamax among others, is a medication used to treat epilepsy and prevent migraines.[2] It has also been used in alcohol dependence.[2] For epilepsy this includes treatment for generalized or focal seizures.[3] It is taken by mouth.[2]

Common side effects include tingling, loss of appetite, feeling tired, abdominal pain, hair loss, and trouble concentrating.[2][3] Serious side effects may include suicide, increased ammonia levels resulting in encephalopathy, and kidney stones.[2] Use in pregnancy may result in harm to the baby and use during breastfeeding is not recommended.[4] How it works is unclear.[2]

Topiramate was approved for medical use in the United States in 1996.[2] It is available as a generic medication.[3] A month supply in the United Kingdom costs the NHS about £1.40 per month as of 2019.[3] In the United States, the wholesale cost of this amount is about US$4.00.[5] In 2017, it was the 77th most commonly prescribed medication in the United States, with more than ten million prescriptions.[6][7]

References[edit]

  1. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 7 August 2020. Retrieved 6 September 2020.
  2. ^ a b c d e f g "Topiramate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 6 March 2019. Retrieved 5 March 2019.
  3. ^ a b c d British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 328. ISBN 9780857113382.
  4. ^ "Topiramate Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 29 August 2021. Retrieved 3 March 2019.
  5. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  6. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
  7. ^ "Topiramate - Drug Usage Statistics". ClinCalc. 23 December 2019. Archived from the original on 28 February 2020. Retrieved 11 April 2020.
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