User:Mr. Ibrahem/Tolazamide

Mr. Ibrahem/Tolazamide
Clinical data
Trade names	Tolinase, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682482
License data	US FDA: Tolazamide;
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth
Drug class	Sulfonylurea
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	?
Metabolism	metabolized in the liver to active metabolites
Onset of action	Within 20 min
Elimination half-life	7 hours
Duration of action	10 hrs
Excretion	Kidney (85%) and fecal (7%)
Identifiers
	IUPAC name N-[(azepan-1-ylamino)carbonyl]-4-methylbenzenesulfonamide;
Chemical and physical data
Formula	C14H21N3O3S
Molar mass	311.40 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(c1ccc(cc1)C)NC(=O)NN2CCCCCC2;
	InChI InChI=1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18) ; Key:OUDSBRTVNLOZBN-UHFFFAOYSA-N ;
	(verify)

Tolazamide, sold under the brand name Tolinase among others, is a medication used to treat type 2 diabetes.^[1] It is taken by mouth.^[1] Effects begin within 20 minutes and last for about 10 hours.^[1]

Common side effects include nausea, loss of appetite, diarrhea, and abdominal pain.^[1] Other side effects may include rash and low blood sugar.^[1] Side effects are more common in people with liver or kidney problems.^[1] It is a sulfonylurea.^[1]

Tolazamide was approved for medical use in the United States in 1966.^[1] It is available as a generic medication.^[2] In the United States 90 tablets of 250 mg costs about 54 USD.^[3]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m "Tolazamide Monograph for Professionals". Drugs.com. Archived from the original on 4 September 2019. Retrieved 5 October 2021.
^ Skyler, Jay (4 April 2012). Atlas of Diabetes. Springer Science & Business Media. p. 186. ISBN 978-1-4614-1027-0. Archived from the original on 9 October 2021. Retrieved 5 October 2021.
^ "Tolazamide Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 5 October 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m "Tolazamide Monograph for Professionals". Drugs.com. Archived from the original on 4 September 2019. Retrieved 5 October 2021.

[2] Skyler, Jay (4 April 2012). Atlas of Diabetes. Springer Science & Business Media. p. 186. ISBN 978-1-4614-1027-0. Archived from the original on 9 October 2021. Retrieved 5 October 2021.

[3] "Tolazamide Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 5 October 2021.

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