User:Mr. Ibrahem/Tobramycin

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Mr. Ibrahem/Tobramycin
Clinical data
Trade namesTobrex, Tobi, others
Other names47663, SPRC-AB01
AHFS/Drugs.comSystemic: Monograph
Eyes: Monograph
MedlinePlusa682660
License data
Pregnancy
category
Routes of
administration		IV, IM, inhalation, eye drop
Drug classAminoglycoside[3]
Legal status
Legal status
  • UK: POM (Prescription only)[4]
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding< 30%
Identifiers
  • (2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol
Chemical and physical data
FormulaC18H37N5O9
Molar mass467.515 g·mol−1
3D model (JSmol)
  • C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H](C[C@@H]([C@H](O3)CN)O)N)N
  • InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1 checkY
  • Key:NLVFBUXFDBBNBW-PBSUHMDJSA-N checkY
  (verify)

Tobramycin is an antibiotic used to treat a variety of infections including sepsis, meningitis, urinary tract infections, bone infections, and lung infections.[5][3] This includes infections due to Pseudomonas.[3] It may be given by injection into a vein or muscle, or inhaled into the lungs.[5]

Common side effects include hearing problems, balance problems, and kidney problems.[3] Other side effects may include paralysis and anaphylaxis.[3] The dose needs to be lowered in those with kidney problems.[3] Use in pregnancy may harm the baby.[3] It is an aminoglycoside.[3]

Tobramycin was patented in 1965, and approved for medical use in 1974.[6] It is available as a generic medication.[5] In the United Kingdom 80 mg for injection costs the NHS about £5 while a month of inhaled medication is about £780.[5] This amount of inhaled solution in the United States costs about 4,900 USD as of 2021.[7] It is made from Streptomyces tenebrarius.[3]

References[edit]

  1. ^ a b "Tobramycin Use During Pregnancy". Drugs.com. 11 November 2019. Archived from the original on 9 August 2020. Retrieved 28 April 2020.
  2. ^ a b "Tobramycin ophthalmic Use During Pregnancy". Drugs.com. 24 December 2019. Archived from the original on 13 April 2020. Retrieved 28 April 2020.
  3. ^ a b c d e f g h i j k "Tobramycin (Systemic) Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 4 October 2021.
  4. ^ "Tobramycin 40mg/ml Injection - Summary of Product Characteristics (SmPC)". (emc). 9 October 2018. Archived from the original on 9 August 2020. Retrieved 28 April 2020.
  5. ^ a b c d e BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 547. ISBN 978-0-85711-369-6.
  6. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 507. ISBN 9783527607495. Archived from the original on 1 August 2020. Retrieved 20 September 2020.
  7. ^ "Tobramycin Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 16 January 2021. Retrieved 5 October 2021.
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