User:Mr. Ibrahem/Terbutaline

Mr. Ibrahem/Terbutaline
	Terbutaline (top),; and (R)-(−)-terbutaline (bottom)
Clinical data
Trade names	Bricanyl, Marex, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682144
Pregnancy; category	AU: A; C;
Routes of; administration	bY MOUTH (tablets, solution), inhalational (DPI, nebulizer solution), SQ
Drug class	β2 adrenergic receptor agonist
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only);
Pharmacokinetic data
Protein binding	25%
Metabolism	GI tract (oral), liver; CYP450: unknown
Elimination half-life	11-16 hours
Excretion	urine 90% (60% unchanged), bile/faeces
Identifiers
	IUPAC name (RS)-5-[2-(tert-Butylamino)-1-hydroxyethyl]benzene-1,3-diol;
Chemical and physical data
Formula	C12H19NO3
Molar mass	225.288 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES Oc1cc(cc(O)c1)C(O)CNC(C)(C)C;
	InChI InChI=1S/C12H19NO3/c1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8/h4-6,11,13-16H,7H2,1-3H3 ; Key:XWTYSIMOBUGWOL-UHFFFAOYSA-N ;
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Terbutaline, sold under the brand names Bricanyl among others, is a medication used for symptoms of asthma or COPD and to temporally delay delivery in preterm labor.^[1] The delay in deliver is used to allow time for steroids to speed lung development in the baby or moving a women to a location with more resources.^[1] It is generally take by mouth, inhaled, or injected under the skin.^[1]^[2]

Common side effects include anxiety, shakiness, fast heart rate, and nausea.^[1] Other side effects may include high blood sugar, low potassium, heart arrhythmia, and insufficient blood flow to the heart.^[1] It should not be used to prevent preterm labor or delay labor more than 48–72 hours.^[3] It is a β₂ adrenergic receptor agonist.^[1]

Terbutaline was patented in 1966 and came into medical use in 1970.^[4] It is available as a generic medication.^[2] In the United Kingdom 100 tablets of 5 mg costs the NHS about 15 pounds.^[2] This amount in the United States costs about 135 USD as of 2021.^[5]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h "Terbutaline Monograph for Professionals". Drugs.com. Archived from the original on 24 June 2021. Retrieved 28 September 2021.
^ ^a ^b ^c BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 270. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ "Archived copy". Archived from the original on 2015-09-21. Retrieved 2015-09-13.{{cite web}}: CS1 maint: archived copy as title (link)
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 542. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2021-07-12.
^ "Terbutaline Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 29 September 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Terbutaline Monograph for Professionals". Drugs.com. Archived from the original on 24 June 2021. Retrieved 28 September 2021.

[BNF80-2] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 270. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[3] "Archived copy". Archived from the original on 2015-09-21. Retrieved 2015-09-13.{{cite web}}: CS1 maint: archived copy as title (link)

[Fis2006-4] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 542. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2021-07-12.

[5] "Terbutaline Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 29 September 2021.

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