User:Mr. Ibrahem/Rimegepant

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Mr. Ibrahem/Rimegepant
Clinical data
Trade namesNurtec ODT, Vydura
Other namesBHV-3000, BMS-927711
AHFS/Drugs.comMonograph
MedlinePlusa620031
License data
Routes of
administration		By mouth
Drug classcalcitonin gene-related peptide receptor antagonist
Legal status
Legal status
Pharmacokinetic data
Onset of actionWith 2 hr[1]
Duration of action48 hr[1]
Identifiers
  • [(5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl] 4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate
Chemical and physical data
FormulaC28H28F2N6O3
Molar mass534.568 g·mol−1
3D model (JSmol)
  • C1CC(C2=C(C=CC=N2)C(C1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
  • InChI=1S/C28H28F2N6O3/c29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37/h1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37)/t18-,22+,24-/m0/s1
  • Key:KRNAOFGYEFKHPB-ANJVHQHFSA-N

Rimegepant, sold under the brand name Nurtec ODT, is a medication used to treat and prevent migraines.[2] It is taken by mouth.[3] Onset is within two hours and effects may last for 48 hours.[1]

Common side effects include nausea and abdominal pain.[2] Other side effects may include allergic reactions.[2] Safety in pregnancy and breastfeeding is unclear.[4] It works by blocking the CGRP receptor.[3]

Rimegepant was approved for medical use in the United States in 2020.[3] In the United States it costs about 120 USD per dose as of 2021.[5] As of 2021 it is not approved in Europe or the United Kingdom.[6]

References[edit]

  1. ^ a b c d Skidmore-Roth, Linda (1 April 2021). Mosby's Drug Guide for Nursing Students with 2022 Update - E-Book. Elsevier Health Sciences. p. 1218. ISBN 978-0-323-87656-8. Archived from the original on 17 October 2021. Retrieved 17 October 2021.
  2. ^ a b c "Nurtec ODT - rimegepant sulfate tablet, orally disintegrating". DailyMed. 19 February 2020. Archived from the original on 28 November 2020. Retrieved 19 March 2020.
  3. ^ a b c "Rimegepant Monograph for Professionals". Drugs.com. Archived from the original on 28 January 2021. Retrieved 17 October 2021.
  4. ^ "Rimegepant (Nurtec ODT) Use During Pregnancy". Drugs.com. Retrieved 17 October 2021.
  5. ^ "Nurtec ODT Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 7 June 2021. Retrieved 17 October 2021.
  6. ^ "Rimegepant". SPS - Specialist Pharmacy Service. 5 October 2017. Archived from the original on 17 October 2021. Retrieved 17 October 2021.
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