User:Mr. Ibrahem/Ranolazine
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| Clinical data | |
|---|---|
| Trade names | Ranexa |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a606015 |
| License data |
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| Routes of administration | By mouth (tablets) |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | 35 to 50% |
| Protein binding | ~62% |
| Metabolism | Extensive in liver (CYP3A, CYP2D6) and intestine |
| Elimination half-life | 7 hours |
| Excretion | Kidney (75%) and fecal (25%) |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C24H33N3O4 |
| Molar mass | 427.545 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
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  (what is this?) (verify) | |
Ranolazine, sold under the brand name Ranexa among others, is a medication used to treat heart related chest pain.[2] Typically it is used together with other medications when those are insufficient.[2][3] Benefits appear smaller in women than men.[2] It is taken by mouth.[2]
Common side effects include constipation, headache, nausea, and dizziness.[2] Serious side effects may include QT prolongation.[2] Use is not recommended in those with liver cirrhosis.[2] How it works is not clear but may involve adenosine triphosphate.[2]
Ranolazine was approved for medical use in the United States in 2006.[2] A month's supply in the United Kingdom costs the NHS about £50 as of 2020.[3] In the United States the wholesale cost of this amount is about $343.[4] In 2017, it was the 273rd most commonly prescribed medication in the United States, with more than one million prescriptions.[5][6]
References[edit]
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 9 August 2020. Retrieved 7 September 2020.
- ^ a b c d e f g h i "Ranolazine Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 31 March 2019. Retrieved 22 March 2019.
- ^ a b BNF (80 ed.). London: BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 224. ISBN 978-0-85711-369-6.
{{cite book}}: CS1 maint: date format (link) - ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
- ^ "Ranolazine - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.