User:Mr. Ibrahem/Nicardipine
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| Clinical data | |
|---|---|
| Trade names | Cardene, others |
| Other names | Nicardipine hydrochloride |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a695032 |
| Routes of administration | By mouth, intravenous |
| Drug class | Calcium channel blocker (dihydropyridine)[1] |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Protein binding | >95% |
| Elimination half-life | 8.6 hours |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C26H29N3O6 |
| Molar mass | 479.533 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 136–138 °C (277–280 °F) |
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| (verify) | |
Nicardipine, sold under the brand name Cardene among others, is a medication used to treat high blood pressure and heart related chest pain.[1] It is also used for Raynaud's phenomenon.[2] It is given by mouth and injected into a vein.[1]
Common side effects include swelling, headache, palpations, and low blood pressure.[1] It should not be used in those with severe aortic stenosis.[1] It may be used in pregnancy.[3] It is a calcium channel blocker of the dihydropyridine class.[1] It works by dilating peripheral arteries.[1]
Nicardipine was patented in 1973 and first approved for medical use in 1981.[4] It was approved in the United States in 1988.[1] It is available as a generic medication.[3] In the United Kingdom 4 weeks of medication costs the NHS about £10 as of 2021.[3] In the United States this amount costs about 130 USD.[5]
References[edit]
- ^ a b c d e f g h i j "Nicardipine Monograph for Professionals". Drugs.com. Archived from the original on 21 September 2021. Retrieved 12 November 2021.
- ^ Pope, J (10 October 2013). "Raynaud's phenomenon (primary)". BMJ clinical evidence. 2013: 1119. PMID 24112969.
- ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 176. ISBN 978-0857114105.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 464. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2021-09-18.
- ^ "Nicardipine Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 22 September 2021. Retrieved 13 November 2021.