User:Mr. Ibrahem/Ibutilide

Mr. Ibrahem/Ibutilide
Clinical data
Trade names	Corvert
AHFS/Drugs.com	Monograph
MedlinePlus	a601248
Pregnancy; category	C;
Routes of; administration	Intravenous
Drug class	Class III antiarrhythmic
Pharmacokinetic data
Bioavailability	N/A
Protein binding	40%
Metabolism	Liver oxidation
Elimination half-life	6 hours (2-12 hours)
Excretion	Kidney (82%), fecal
Identifiers
	IUPAC name N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide;
Chemical and physical data
Formula	C20H36N2O3S
Molar mass	384.58 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(Nc1ccc(cc1)C(O)CCCN(CC)CCCCCCC)C;
	InChI InChI=1S/C20H36N2O3S/c1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25/h12-15,20-21,23H,4-11,16-17H2,1-3H3 ; Key:ALOBUEHUHMBRLE-UHFFFAOYSA-N ;
	(verify)

Ibutilide, sold under the brand name Corvert, is a medication used to try to convert atrial fibrillation and atrial flutter of a recent onset.^[1] It is given by gradual injection into a vein.^[1]

Relatively common side effects include palpitations, low blood pressure, nausea, and headache.^[1] Other side effects may include torsades de pointes and AV block.^[1] Safety in pregnancy is unclear.^[1] It is a class III antiarrhythmic and works by prolonging the action potential.^[1]^[2]

Ibutilide was approved for medical use in the United States in 1995.^[1] It is approved in part of Europe but not the United Kingdom.^[3] In the United States it costs about 325 USD for a 1 mg dose as of 2021.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Ibutilide Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 24 November 2021.
^ "DailyMed - CORVERT- ibutilide fumarate injection, solution". dailymed.nlm.nih.gov. Archived from the original on 11 December 2021. Retrieved 25 November 2021.
^ "List of nationally authorised medicinal products Active substance: ibutilide" (PDF). Archived (PDF) from the original on 19 September 2020. Retrieved 25 November 2021.
^ "Ibutilide Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 25 November 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Ibutilide Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 24 November 2021.

[PI2021-2] "DailyMed - CORVERT- ibutilide fumarate injection, solution". dailymed.nlm.nih.gov. Archived from the original on 11 December 2021. Retrieved 25 November 2021.

[3] "List of nationally authorised medicinal products Active substance: ibutilide" (PDF). Archived (PDF) from the original on 19 September 2020. Retrieved 25 November 2021.

[4] "Ibutilide Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 25 November 2021.

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