User:Mr. Ibrahem/Etacrynic acid

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Mr. Ibrahem/Etacrynic acid
Clinical data
Trade namesEdecrin, others
Other namesEthacrynic acid, ethacrynate sodium
AHFS/Drugs.comMonograph
MedlinePlusa682857
Routes of
administration		By mouth, IV
Drug classLoop diuretic[1]
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding> 98%
Identifiers
  • [2,3-dichloro-4-(2-methylenebutanoyl)phenoxy]acetic acid
Chemical and physical data
FormulaC13H12Cl2O4
Molar mass303.14 g·mol−1
3D model (JSmol)
  • O=C(O)COc1c(Cl)c(Cl)c(cc1)C(=O)C(=C)CC
  • InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17) checkY
  • Key:AVOLMBLBETYQHX-UHFFFAOYSA-N checkY
  (verify)

Etacrynic acid, also known as ethacrynic acid and sold under brand name Edecrin among others, is a medication used to treat swelling caused by heart failure, liver failure, and kidney problems and for high blood pressure.[1] In high blood pressure it is not a preferred option.[1] Other uses may include high calcium and diabetes insipidus.[1] It may be taken by mouth or injected into a vein.[1]

Common side effects include nausea, diarrhea, high blood sugar, gout, hearing problems, headache, tiredness, rash, and world spinning.[1] Other side effects may include low potassium, low blood pressure with standing, and kidney problems.[1] It is is a loop diuretic.[1] It has the benefit of being usable in people who are allergic to sulfonamides.[3]

Etacrynic acid was approved for medical use in the United States in 1967.[1] It is also available in Canada.[4] In the United States 90 tablets of 25 mg costs about 65 USD as of 2021.[5] It; however, is rarely used.[2]

References[edit]

  1. ^ a b c d e f g h i j k "Ethacrynic Acid Monograph for Professionals". Drugs.com. Archived from the original on 21 March 2016. Retrieved 16 December 2021.
  2. ^ a b "Loop Diuretics". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 7 November 2020. Retrieved 16 December 2021.
  3. ^ Somberg JC, Molnar J (January 2009). "The pleiotropic effects of ethacrynic acid". American Journal of Therapeutics. 16 (1): 102–4. doi:10.1097/MJT.0b013e3181961264. PMID 19142157.
  4. ^ "Health and Community Services". www.health.gov.nl.ca. Archived from the original on 11 January 2022. Retrieved 16 December 2021.
  5. ^ "Ethacrynic Acid Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 16 December 2021.
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