User:Mr. Ibrahem/Erenumab
 A standard 70mg/mL Aimovig autoinjector | |
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | CGRPR |
| Clinical data | |
| Trade names | Aimovig |
| Other names | AMG-334, erenumab-aooe |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a618029 |
| License data | |
| Pregnancy category |
|
| Routes of administration | Subcutaneous injection |
| Drug class | CGRPR blocker[2] |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | 82% (estimated) |
| Metabolism | Proteolysis |
| Elimination half-life | 28 days |
| Chemical and physical data | |
| Formula | C6472H9964N1728O2018S50 |
| Molar mass | 145871.98 g·mol−1 |
Erenumab, sold under the brand name Aimovig, is a medication used to prevent migraine headaches.[3] It is used in those who have at least 4 headaches a month.[4] It is given by injection under the skin.[3]
Common side effects include constipation and muscle spasms.[2] Other side effects may include swelling due to fluid retention.[2] While there is no evidence of harm with use in prenancy, such use has not been well studied.[5] It is a monoclonal antibody that binds to and blocks calcitonin gene-related peptide receptor (CGRPR).[2]
Erenumab was approved for medical use in the United States and Europe in 2018.[3][4] In the United Kingdom it costs about £390 every 4 weeks as of 2021.[2] This amount in the United States is about 630 USD.[6]
References[edit]
- ^ a b "Erenumab (Aimovig) Use During Pregnancy". Drugs.com. 17 April 2019. Archived from the original on 29 November 2020. Retrieved 5 May 2020.
- ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 498. ISBN 978-0857114105.
- ^ a b c d "Erenumab-aooe Monograph for Professionals". Drugs.com. Archived from the original on 3 March 2021. Retrieved 15 December 2021.
- ^ a b "Aimovig". Archived from the original on 17 October 2020. Retrieved 15 December 2021.
- ^ "Erenumab (Aimovig) Use During Pregnancy". Drugs.com. Archived from the original on 29 November 2020. Retrieved 15 December 2021.
- ^ "Aimovig Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 11 January 2022. Retrieved 15 December 2021.