User:Mr. Ibrahem/Baloxavir marboxil

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Baloxavir marboxil
Clinical data
Trade namesXofluza
Other namesBaloxavir acid (BXA), BXM (S-033188), BXA (S-033447)
AHFS/Drugs.comMonograph
MedlinePlusa618062
License data
Pregnancy
category
Routes of
administration		By mouth
Drug classAntiviral
Legal status
Legal status
  • AU: S4 (Prescription only)[1]
  • US: ℞-only[2]
  • EU: Rx-only[3]
  • In general: ℞ (Prescription only)
Identifiers
  • ({(12aR)-12-[(11S)-7,8-Difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-6,8-dioxo-3,4,6,8,12,12a-hexahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl}oxy)methyl methyl carbonate
Chemical and physical data
FormulaC27H23F2N3O7S
Molar mass571.55 g·mol−1
3D model (JSmol)
  • O=C(OCOC(C(C=C1)=O)=C(N1N([C@@H]2C3=CC=CC=C3SCC4=C(F)C(F)=CC=C24)[C@@]5([H])N6CCOC5)C6=O)OC
  • InChI=1S/C27H23F2N3O7S/c1-36-27(35)39-14-38-25-19(33)8-9-31-24(25)26(34)30-10-11-37-12-21(30)32(31)23-15-6-7-18(28)22(29)17(15)13-40-20-5-3-2-4-16(20)23/h2-9,21,23H,10-14H2,1H3/t21-,23+/m1/s1
  • Key:RZVPBGBYGMDSBG-GGAORHGYSA-N

Baloxavir marboxil (BXM), sold under the brand name Xofluza, is an antiviral used to treat and prevent influenza (flu).[2] It is used in those over the age of 11 who have been sick for less than 48 hours.[2] It decreases recover time by about a day.[3] It is taken by mouth as a single dose.[2]

Common side effects include diarrhea, bronchitis, nausea, sinusitis, and headache.[2] Other side effects may include anaphylaxis.[2] Safety in pregnancy is unclear.[2] It is a influenza virus polymerase acidic (PA) endonuclease inhibitor.[2]

Baloxavir marboxil was approved for medical use in the United States and Japan in 2018.[2][4] It was approved in Europe and the United Kingdom in 2021.[5] In the United States a course of treatment costs about 160 USD as of 2022.[6]

References[edit]

  1. ^ a b "Xofluza Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). 2 March 2020. Archived from the original on 13 March 2020. Retrieved 16 August 2020.
  2. ^ a b c d e f g h i j k l "Xofluza- baloxavir marboxil tablet, film coated". DailyMed. 28 October 2019. Archived from the original on 28 October 2020. Retrieved 9 January 2020.
  3. ^ a b "Xofluza EPAR". European Medicines Agency (EMA). 9 November 2020. Archived from the original on 30 January 2021. Retrieved 25 January 2021.
  4. ^ Heo, Young-A (April 2018). "Baloxavir: First Global Approval". Drugs. 78 (6): 693–697. doi:10.1007/s40265-018-0899-1.
  5. ^ "Baloxavir marboxil". SPS - Specialist Pharmacy Service. 29 June 2018. Archived from the original on 26 July 2020. Retrieved 8 January 2022.
  6. ^ "Baloxavir Marboxil Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 8 January 2022.
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