User:Mr. Ibrahem/Alvimopan

Mr. Ibrahem/Alvimopan
Clinical data
Trade names	Entereg
Other names	Alvimopan, Entereg
AHFS/Drugs.com	Monograph
MedlinePlus	a608051
License data	US FDA: Alvimopan;
Routes of; administration	By mouth
Drug class	Peripherally acting μ-opioid receptor antagonist
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	6%
Protein binding	80% (parent drug), 94% (metabolite)
Metabolism	Gut microflora-mediated hydrolysis to active metabolite
Elimination half-life	10-17 hours
Excretion	Faeces, urine (35%)
Identifiers
	IUPAC name 2-([(2S)-2-([(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl) -3-phenylpropanoyl]amino)acetic acid;
Chemical and physical data
Formula	C25H32N2O4
Molar mass	424.541 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)CNC(=O)[C@@H](Cc1ccccc1)CN3CC[C@@](c2cccc(O)c2)([C@H](C3)C)C;
	InChI InChI=1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1 ; Key:UPNUIXSCZBYVBB-JVFUWBCBSA-N ;
	(what is this?) (verify)

Alvimopan, sold under the brand name Entereg, is a medication used to speed recovery from ileus after partial bowel resection with surgical anastomosis.^[2] It may be used after either small bowel or large bowel surgery.^[1] It is taken by mouth.^[1]

Common side effects include heart burn.^[2] Other side effects may include a heart attack and low potassium.^[2]^[1] Safety in pregnancy is unclear.^[3] It is a peripherally acting μ-opioid receptor antagonist.^[1]

Alvimopan was approved for medical use in the United States in 2008.^[2] In the United States 15 doses of 12 mg costs about 2,900 USD as of 2022.^[4]

References[edit]

^ ^a ^b ^c ^d ^e "Alvimopan Monograph for Professionals". Drugs.com. Archived from the original on 28 June 2021. Retrieved 14 January 2022.
^ ^a ^b ^c ^d ^e ^f ^g "DailyMed - ALVIMOPAN capsule". dailymed.nlm.nih.gov. Archived from the original on 19 April 2021. Retrieved 14 January 2022.
^ "Alvimopan (Entereg) Use During Pregnancy". Drugs.com. Archived from the original on 3 December 2020. Retrieved 14 January 2022.
^ "Entereg Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 14 January 2022.

[AHFS2022-1] "Alvimopan Monograph for Professionals". Drugs.com. Archived from the original on 28 June 2021. Retrieved 14 January 2022.

[PI2022-2] ^ ^a ^b ^c ^d ^e ^f ^g "DailyMed - ALVIMOPAN capsule". dailymed.nlm.nih.gov. Archived from the original on 19 April 2021. Retrieved 14 January 2022.

[3] "Alvimopan (Entereg) Use During Pregnancy". Drugs.com. Archived from the original on 3 December 2020. Retrieved 14 January 2022.

[4] "Entereg Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 14 January 2022.

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