Talk:Dopamine beta hydroxylase deficiency
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Dopamine Beta Hydroxylase Deficiency and Psychiatric Involvement[edit]
In this, there is a "five- to tenfold elevation of plasma dopamine" and almost non-existant or low levels of epinephrine. Therefore, it is almost incompresensable that there would be no neuropsychiatric involvement.However, the symptoms are not limited to that aspect of this disorder. According to one study by the NIH, 100% of individuals studied suffered severe orthostatic hypotension, 80% suffered anemia, 43% epileptic symptoms, 100% nasal stuffiness, 33% suffered hypoglycemia, 60% frequent urination and nighttime frequent urination, 50% muscle hypotonia, 75% postpranial hypotension, and 100% suffered from sleep problems. "Several polymorphisms in the DBH gene have been identified. Linkage and association studies have been conducted with these polymorphisms in individuals with schizophrenia, migraine, attention deficit/hyperactivity disorder, Parkinson disease, and alcoholism, with mixed results." "Since the discovery that the antipsychotic action of phenothiazines was mediated by dopamine D2 receptors, the dopamine system has been scrutinized for schizophrenia related abnormalities."[1] If the D2 receptors mediates are where antipsychotics activates, and drugs like domperidone also mediate the D2 receptors then why can't that treat schizophrenia with fewer side effects than typical and atipical antipsychotics?
Comment[edit]
Seems like OR and argumentation rather than verifiable content. Tim Vickers (talk) 20:47, 25 February 2009 (UTC)