User talk:Mileshillie

Sam hillie

A tag has been placed on Sam hillie, requesting that it be speedily deleted from Wikipedia. This has been done because the article seems to be about a person, group of people, band, club, company, or web content, but it does not indicate how or why the subject is notable (see the guidelines for notability here). If you can indicate why the subject of this article is notable, you may contest the tagging. To do this, please add {{hangon}} on the top of the page and leave a note on the article's talk page explaining your position. Please do not remove the speedy deletion tag yourself.

Please read the criteria for speedy deletion (specifically, articles #7) and our general biography criteria. Feel free to leave a note on my talk page if you have any questions about this. Kon-Tiki001 22:26, 27 November 2006 (UTC)

Rattlesnake venom

Hi, Mileshillie! I just saw your edits to Crotalus atrox and Crotalus adamanteus regarding venom. That's some interesting information, but can you supply us with a reference for where you got it? If you do, then maybe we'll not only let it stand, but also move to Crotalus, since it seems to apply to the entire genus. (PS -- You can reply here, since I've temporarily added this page to my watchlist). --Jwinius 03:44, 2 December 2006 (UTC)

I left what I felt to be a decent reference, though it isn't entirely focused on the proteolytic effects of rattlesnake venom; instead it focuses on certain mammals' tendency to resist these effects. It does, however, give information on the proteolytic venom found in rattlesnakes in the first paragraph (and loosely in subsequent paragraphs):

"In snake venoms that cause extensive hemorrhage, such as those of rattlesnakes and other vipers and pitvipers, the toxins responsible for hemorrhage have been identified as snake venom metalloproteases (SVMPs). These enzymatic toxins cause localized hemorrhage, either through damage to endothelial cells (Ownby et al. 1978; Ownby and Geren, 1987) or through gaps produced between endothelial cells as a result of damage to the basement membrane of blood vessels (Ohsaka, 1979; Markland, 1998). Hemorrhage produced by SVMPs can subsequently lead to edema, shock, tissue necrosis, and reduced ability to regenerate muscle tissue (Gutiérrez and Rucavado, 2000). Additionally, leakage of blood from affected vessels also helps spread other venom toxins to their target tissues."

So while hemotoxic hemorrhaging is the rattlesnake's predominant toxic effect, it's venom is not solely a hemotoxin. Perhaps I should have, or should, make that clear in the article.

aside from all that... I saw my first wild rattlesnake (eastern diamondback) down here in the sunshine state a couple weeks ago. It looked to be about 4 or 5 ft long and crossing a road near my house. I couldn't get it to rattle it's tail though... dang...

--the oreo 17:15, 2 December 2006 (UTC)

Your reference -- Ho CYL. 2005. Purification of Metalloprotease Inhibitors That Neutralize Snake Venom Toxins in California Ground Squirrel Blood. Explorations. 8 pp. PDF -- is indeed where you got the above quote, but not the information you added to the articles for C. adamanteus and C. atrox. Specifically:

"Proteolytic venoms are, in fact, advanced and concentrated fluids that destroy tissues and other cells through intramolecular digestion. A few toxic effects include: cytotoxic (destoys cells), hemotoxic (destroys red blood cells), myotoxic (causes paralysis and muscle destruction), hemorrhagic (causes persistent bleeding) ... Rattlesnakes have the most potent hemotoxic venom of any snake, making them one of the most dangerous snakes in the world."

Where did you get this information?? You need to provide a specific reference. --Jwinius 20:45, 2 December 2006 (UTC)

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