User:Shembody/sandbox
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| Submission declined on 17 December 2023 by KylieTastic (talk). The submission appears to be written in Japanese. This is the English language Wikipedia; we can only accept articles written in the English language. Please provide a high-quality English language translation of your submission. Otherwise, you may write it in the Japanese Wikipedia. Declined by KylieTastic 5 months ago. | |
Comment: Still not English KylieTastic (talk) 17:53, 17 December 2023 (UTC)
バングレン[edit]
バングレン（Banglen）は、インドネシアのジャワしょうが「バングレ（Bangle）」（学名: Zingiber purpureum）にのみ含有するフェニルブテノイド2量体（Phenylbutenoid dimers）である[1]。バングレンが認知症などの神経疾患に対して、副作用なく継続可能な治療薬・サプリメントへの応用が期待されており、バングレンを高濃度に含有したものとして「メモリック®️」がある。
| 特性 | |
|---|---|
| 化学式 | C24H28O4 |
| モル質量 | 380.484 |
| 外観 | 白色粉末 |
生理活性[edit]
バングレンの最も注目すべき健康機能性は、脳機能改善作用である。バングレンにはニューロンを伸展させる効果があることが、PC12細胞やヒト神経幹細胞を用いたin vitro試験で明らかになっている[2][3][4]。また、in vivo試験にてバングレンによる慢性治療が海馬の神経新生を増強することで学習能力・記憶力を改善することが示唆される[4]。
ヒトでの効果[edit]
ヒトにおける試験では、軽度認知障害（mild cognitive impairment ：MCI）の被験者において、認知機能検査法のMoca-Jによって「記憶/遅延再生」や「注意」領域において有意に改善することが報告された[5]。
- ^ "ジャワしょうが - 株式会社ホソダSHC". www.hosoda-shc.co.jp. Retrieved 2023-12-17.
- ^ Matsui, Nobuaki; Kido, Yuki; Okada, Hideki; Kubo, Miwa; Nakai, Megumi; Fukuishi, Nobuyuki; Fukuyama, Yoshiyasu; Akagi, Masaaki (2012-03-28). "Phenylbutenoid dimers isolated from Zingiber purpureum exert neurotrophic effects on cultured neurons and enhance hippocampal neurogenesis in olfactory bulbectomized mice". Neuroscience Letters. 513 (1): 72–77. doi:10.1016/j.neulet.2012.02.010. ISSN 0304-3940. PMID 22343027.
- ^ Kubo, Miwa; Gima, Minori; Baba, Kohei; Nakai, Megumi; Harada, Kenichi; Suenaga, Midori; Matsunaga, Yoichi; Kato, Eishin; Hosoda, Shinya; Fukuyama, Yoshiyasu (2015-04-01). "Novel neurotrophic phenylbutenoids from Indonesian ginger Bangle, Zingiber purpureum". Bioorganic & Medicinal Chemistry Letters. 25 (7): 1586–1591. doi:10.1016/j.bmcl.2015.02.005. ISSN 0960-894X. PMID 25728129.
- ^ a b Nakai, Megumi; Iizuka, Michiro; Matsui, Nobuaki; Hosogi, Kazuko; Imai, Akiko; Abe, Noriaki; Shiraishi, Hisashi; Hirata, Ayumu; Yagi, Yusuke; Jobu, Kohei; Yokota, Junko; Kato, Eishin; Hosoda, Shinya; Yoshioka, Saburo; Harada, Kenichi (May 2016). "Bangle (Zingiber purpureum) Improves Spatial Learning, Reduces Deficits in Memory, and Promotes Neurogenesis in the Dentate Gyrus of Senescence-Accelerated Mouse P8". Journal of Medicinal Food. 19 (5): 435–441. doi:10.1089/jmf.2015.3562. ISSN 1096-620X. PMID 26829513.
- ^ [chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.jstage.jst.go.jp/article/jcam/15/1/15_65/_pdf "ジャワしょうが抽出物摂取の軽度認知障害に対する影響"]. 日本補完代替医療学会雑誌.
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