User:Mr. Ibrahem/Selpercatinib
Clinical data | |
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Trade names | Retevmo, Retsevmo |
Other names | LOXO-292 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a620036 |
License data |
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Pregnancy category |
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Routes of administration | By mouth |
Drug class | Tyrosine kinase inhibitor |
Legal status | |
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Identifiers | |
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Chemical and physical data | |
Formula | C29H31N7O3 |
Molar mass | 525.613 g·mol−1 |
3D model (JSmol) | |
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Selpercatinib, sold under the brand name Retevmo, is a medication used to treat certain types of non-small cell lung cancer and thyroid cancer.[3] It is used in cases that are either RET fusion positive or have a RET gene mutation.[3][1] It is used after other treatments have failed.[5] It is taken by mouth.[1]
Common side effects include liver problems, high blood sugar, dry mouth, diarrhea, kidney problems, tiredness, swelling, low platelets, and rash.[1] Other side effects may include high blood pressure, QT prolongation, bleeding, allergic reactions, and tumor lysis syndrome.[1] Use in pregnancy may harm the baby.[1] It is a kinase inhibitor, which blocks RET.[1]
Selpercatinib was approved for medical use in the United States in 2020 and Europe in 2021.[3][4] In the United States it costs about 258,000 USD per year as of 2021.[6] It has also bee approved in the United Kingdom.[5]
References[edit]
- ^ a b c d e f g h "Retevmo- selpercatinib capsule". DailyMed. Archived from the original on 4 March 2021. Retrieved 31 March 2021.
- ^ "Retsevmo EPAR". European Medicines Agency (EMA). 9 December 2020. Archived from the original on 23 April 2021. Retrieved 23 April 2021.
- ^ a b c d "Selpercatinib Monograph for Professionals". Drugs.com. Archived from the original on 21 November 2021. Retrieved 12 October 2021.
- ^ a b "Retsevmo". Archived from the original on 23 April 2021. Retrieved 12 October 2021.
- ^ a b "Selpercatinib". SPS - Specialist Pharmacy Service. 14 February 2020. Archived from the original on 28 October 2020. Retrieved 12 October 2021.
- ^ "Retevmo Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 12 October 2021.