User:Mr. Ibrahem/Pemetrexed

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Mr. Ibrahem/Pemetrexed
Clinical data
Trade namesAlimta, Pemfexy, Ciambra, others
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: D
Routes of
administration		Intravenous
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only[1]
  • EU: Rx-only
Pharmacokinetic data
BioavailabilityNA
Protein binding81%
MetabolismNegligible
Elimination half-life3.5 hours
ExcretionKidney
Identifiers
  • (2S)-2-{[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino}pentanedioic acid
Chemical and physical data
FormulaC20H21N5O6
Molar mass427.417 g·mol−1
3D model (JSmol)
  • Nc3nc2[nH]cc(CCc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)c2c(=O)[nH]3
  • InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1 checkY
  • Key:WBXPDJSOTKVWSJ-ZDUSSCGKSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Pemetrexed, sold under the brand name Alimta among others, is a medication used to treat mesothelioma and non-small cell lung cancer (NSCLC).[2] It is used for mesothelioma which involves the pleura and cannot be removed by surgery.[3] It is given by gradual injection into a vein.[2]

Common side effects include fever, infection, inflammation of the mouth, rash, nausea, tiredness, shortness of breath, and chest pain.[3] Other side effects may include bone marrow suppression.[3] Use in pregnancy may harm the baby.[3] It works by blocking the creation of DNA and RNA by inhibiting thymidylate transferase.[4][2]

Pemetrexed was approved for medical use in the United States and Europe in 2004.[4][3] It is available as a generic medication.[2] In the United Kingdom 500 mg costs the NHS about £450 as of 2021.[2] This amount in the United States is about 3,700 USD.[5]

References[edit]

  1. ^ "Alimta- pemetrexed disodium injection, powder, lyophilized, for solution". DailyMed. 25 March 2020. Archived from the original on 20 October 2020. Retrieved 20 October 2020.
  2. ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 960. ISBN 978-0857114105.
  3. ^ a b c d e f g "PEMEtrexed Monograph for Professionals". Drugs.com. Archived from the original on 20 April 2019. Retrieved 27 October 2021.
  4. ^ a b "Alimta". Archived from the original on 18 January 2021. Retrieved 27 October 2021.
  5. ^ "Pemetrexed Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 27 October 2021.
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