User:Mr. Ibrahem/Oxandrolone

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Mr. Ibrahem/Oxandrolone
Clinical data
Trade namesOxandrin, Anavar, others
Other namesVar; CB-8075; NSC-67068; SC-11585; Protivar; 17α-Methyl-2-oxa-4,5α-dihydrotestosterone; 17α-Methyl-2-oxa-DHT; 17α-Methyl-2-oxa-5α-androstan-17β-ol-3-one
AHFS/Drugs.comMonograph
MedlinePlusa604024
Pregnancy
category
  • X
Routes of
administration		By mouth
Drug classAndrogen; anabolic steroid
Legal status
Legal status
Pharmacokinetic data
Bioavailability97%[1]
Protein binding94–97%[1]
MetabolismKidneys (primarily), liver[3][1]
Elimination half-lifeAdults: 9.4–10.4 hours[1][2]
Elderly: 13.3 hours[2]
ExcretionUrine: 28% (unchanged)[2]
Feces: 3%[2]
Identifiers
  • (1S,3aS,3bR,5aS,9aS,9bS,11aS)-1-hydroxy-1,9a,11a-trimethyl-2,3,3a,3b,4,5,5a,6,9,9b,10,11-dodecahydroindeno[4,5-h]isochromen-7-one
Chemical and physical data
FormulaC19H30O3
Molar mass306.446 g·mol−1
3D model (JSmol)
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C)O)CC[C@@H]4[C@@]3(COC(=O)C4)C
  • InChI=1S/C19H30O3/c1-17-11-22-16(20)10-12(17)4-5-13-14(17)6-8-18(2)15(13)7-9-19(18,3)21/h12-15,21H,4-11H2,1-3H3/t12-,13+,14-,15-,17-,18-,19-/m0/s1 checkY
  • Key:QSLJIVKCVHQPLV-PEMPUTJUSA-N checkY
  (verify)

Oxandrolone, sold under the brand names Oxandrin among others, is a manufactured androgen and anabolic steroid (AAS).[4] It is used to promote weight gain in those losing weight, prevent protein breakdown caused by long-term corticosteroids, and bone pain associated with osteoporosis.[4][5] It is taken by mouth.[4]

Common side effects include liver problems and lipid abnormalities.[4] Other side effects may include heart failure, misuse, acne, increased hair growth, and voice changes.[4] Use during pregnancy may harm the baby.[4] Oxandrolone activates the androgen receptor (AR), the biological target of testosterone.[6] It has greater anabolic than androgenic effects.[4]

Oxandrolone was approved for medical use in the United States in 1964.[4] It is not medically available in the United Kingdom.[6] In the United States 60 tablets of 10 mg costs about 284 USD as of 2020.[7] It has also been inappropriately used to improve physique and performance in sports.[4] It is a controlled substance in many countries, so nonmedical is generally illegal.[8][9][10]

References[edit]

  1. ^ a b c d Ashraf Mozayani; Lionel Raymon (15 October 2003). Handbook of Drug Interactions: A Clinical and Forensic Guide. Springer Science & Business Media. pp. 513–. ISBN 978-1-59259-654-6. Archived from the original on 15 December 2019. Retrieved 6 November 2017.
  2. ^ a b c d Miller JT, Btaiche IF (February 2009). "Oxandrolone treatment in adults with severe thermal injury" (PDF). Pharmacotherapy. 29 (2): 213–26. doi:10.1592/phco.29.2.213. hdl:2027.42/90285. PMID 19170590. S2CID 25780591. Archived from the original on 2021-08-29. Retrieved 2019-08-30.
  3. ^ R.A.S Hemat (2 March 2003). Andropathy. Urotext. pp. 108–. ISBN 978-1-903737-08-8. Archived from the original on 2021-07-25. Retrieved 2017-11-06.
  4. ^ a b c d e f g h i j k "Oxandrolone Monograph for Professionals". Drugs.com. Archived from the original on 27 February 2021. Retrieved 14 December 2020.
  5. ^ a b Li H, Guo Y, Yang Z, Roy M, Guo Q (June 2016). "The efficacy and safety of oxandrolone treatment for patients with severe burns: A systematic review and meta-analysis". Burns. 42 (4): 717–27. doi:10.1016/j.burns.2015.08.023. PMID 26454425.
  6. ^ a b Kicman AT (June 2008). "Pharmacology of anabolic steroids". British Journal of Pharmacology. 154 (3): 502–21. doi:10.1038/bjp.2008.165. PMC 2439524. PMID 18500378.
  7. ^ "Oxandrolone Prices, Coupons & Savings Tips". GoodRx. Archived from the original on 9 November 2016. Retrieved 14 December 2020.
  8. ^ "Controlled Substances Act". United States Food and Drug Administration. 11 June 2009. Archived from the original on 2 March 2017. Retrieved 17 June 2016.
  9. ^ Branch, Legislative Services. "Consolidated federal laws of Canada, Controlled Drugs and Substances Act". laws-lois.justice.gc.ca. Archived from the original on 2017-02-05. Retrieved 2017-01-14.
  10. ^ "List of most commonly encountered drugs currently controlled under the misuse of drugs legislation - GOV.UK". www.gov.uk. Archived from the original on 2019-12-08. Retrieved 2017-01-14.
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