User:Mr. Ibrahem/Guaifenesin
 | |
| Clinical data | |
|---|---|
| Pronunciation | /ɡwaɪˈfɛnɪsɪn/ |
| Trade names | Mucinex, others |
| Other names | Glyceryl guaiacolate |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682494 |
| License data |
|
| Routes of administration | By mouth (tablets, syrup) |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Metabolism | Kidney |
| Elimination half-life | 1–5 hours[1] |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C10H14O4 |
| Molar mass | 198.218 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
| |
| |
| (verify) | |
Guaifenesin, sold under the brand name Mucinex among others,[3] is a medication used to try to help cough out phlegm from the airways.[2] It is unclear if it decreases coughing.[2] Use is not recommended in children less than 6 years old.[5] It is often used in combination with other medications.[2] It is taken by mouth.[2]
Side effects may include dizziness, sleepiness, skin rash, and nausea.[3] While it has not been properly studied in pregnancy, it appears to be safe.[6] It is believed to work by making airway secretions more liquid.[2]
Guaifenesin has been used medically since at least 1933.[7] It is available as a generic medication and over the counter.[2][6] In the United States the wholesale cost is less than US$0.10 per dose.[8] In 2017, it was the 234th most commonly prescribed medication in the United States, with more than two million prescriptions.[9][10]
References[edit]
- ^ Aluri JB, Stavchansky S (1993). "Determination of guaifenesin in human plasma by liquid chromatography in the presence of pseudoephedrine". J Pharm Biomed Anal. 11 (9): 803–8. doi:10.1016/0731-7085(93)80072-9. PMID 8218524. Archived from the original on 2021-08-28. Retrieved 2022-03-14.
- ^ a b c d e f g "Guaifenesin Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 15 April 2019. Retrieved 25 March 2019.
- ^ a b c "Guaifenesin". Drugs.com. Archived from the original on 2017-12-29. Retrieved 2019-03-25.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 7 August 2020. Retrieved 9 September 2020.
- ^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 295. ISBN 9780857113382.
- ^ a b Weiner, Carl P.; Rope, Kate (2013). The Complete Guide to Medications During Pregnancy and Breastfeeding: Everything You Need to Know to Make the Best Choices for You and Your Baby. St. Martin's Press. p. PT282. ISBN 9781250037206.
- ^ Riviere, Jim E.; Papich, Mark G. (2013). Veterinary Pharmacology and Therapeutics. John Wiley & Sons. p. 287. ISBN 9781118685907. Archived from the original on 2019-03-27. Retrieved 2019-03-25.
- ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
- ^ "Guaifenesin - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.