User:Mr. Ibrahem/Golimumab
 Cartoon representation of the antibody Golimumab. The heavy and light chains are coloured blue and yellow respectively. From PDB entry 5yoy | |
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | TNFα |
| Clinical data | |
| Trade names | Simponi, Simponi Aria |
| Other names | CNTO-148[1] |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a610010 |
| License data | |
| Pregnancy category |
|
| Routes of administration | Subcutaneous injection |
| Legal status | |
| Legal status | |
| Chemical and physical data | |
| Formula | C6530H10068N1752O2026S44 |
| Molar mass | 146945.25 g·mol−1 |
  (what is this?) (verify) | |
Golimumab, sold under the brand name Simponi, is a medication used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis.[5][4] It is given by injection under the skin.[5]
Common side effects include upper respiratory tract infection.[4] Other side effects may include sepsis, pneumonia, reactivation of hepatitis B, heart failure, allergic reactions, vasculitis, and leukemia.[4] Use in pregnancy and breastfeeding is of unclear safety.[6] It is a monoclonal antibody which is attaches to and blocks tumor necrosis factor alpha (TNF-alpha), a pro-inflammatory molecule.[4]
Golimumab was approved for medical use in the United States and Europe in 2009.[5][4] It is on the World Health Organization's List of Essential Medicines as an alternative to adalimumab.[7] In the United Kingdom 100 mg costs the NHS about £1,500 as of 2021.[8] In the United States this amount costs about 6,300 USD.[9]
References[edit]
- ^ Mazumdar S, Greenwald D (2009). "Golimumab". mAbs. 1 (5): 422–31. doi:10.4161/mabs.1.5.9286. PMC 2759491. PMID 20065639. Archived from the original on 2014-08-08. Retrieved 2021-10-04.
- ^ "Simponi- golimumab injection, solution". DailyMed. 30 September 2019. Archived from the original on 25 March 2021. Retrieved 11 November 2020.
- ^ "Simponi Aria- golimumab solution". DailyMed. 2 October 2020. Archived from the original on 24 March 2021. Retrieved 11 November 2020.
- ^ a b c d e f g h "Simponi EPAR". European Medicines Agency (EMA). Archived from the original on 11 November 2020. Retrieved 11 November 2020.
- ^ a b c d "Golimumab Monograph for Professionals". Drugs.com. Archived from the original on 9 July 2018. Retrieved 9 December 2021.
- ^ "Golimumab Use During Pregnancy". Drugs.com. Archived from the original on 29 October 2020. Retrieved 9 December 2021.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1162. ISBN 978-0857114105.
- ^ "Simponi Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 20 January 2021. Retrieved 9 December 2021.