User:Mr. Ibrahem/Brivaracetam

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Mr. Ibrahem/Brivaracetam
Clinical data
Pronunciation/ˌbrɪvəˈræsətəm/ BRIV-ə-RASS-ə-təm
Trade namesBriviact, Nubriveo, Brivazen, others
AHFS/Drugs.comMonograph
MedlinePlusa616027
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth, intravenous
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: Schedule V[1]
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityNearly 100%
Protein binding≤20%
MetabolismHydrolysis by amidase, CYP2C19-mediated hydroxylation
Metabolites3 inactive metabolites
Elimination half-life≈9 hours
ExcretionKidneys (>95%)[1]
Identifiers
  • (2S)-2-[(4R)-2-oxo-4-propylpyrrolidin-1-yl] butanamide
Chemical and physical data
FormulaC11H20N2O2
Molar mass212.293 g·mol−1
3D model (JSmol)
Specific rotation[α]D −60°
Melting point72 to 77 °C (162 to 171 °F)
  • O=C(N)[C@@H](N1C(=O)C[C@@H](CCC)C1)CC
  • InChI=1S/C11H20N2O2/c1-3-5-8-6-10(14)13(7-8)9(4-2)11(12)15/h8-9H,3-7H2,1-2H3,(H2,12,15)/t8-,9+/m1/s1 checkY
  • Key:MSYKRHVOOPPJKU-BDAKNGLRSA-N checkY

Brivaracetam, sold under the brand name Briviact among others, is a medication used to treat epilepsy, specifically partial-onset seizures.[2] It is used in people over the age of 3 together with other epilepsy medicines.[2] It may be taken by mouth or injected into a vein.[4]

Common side effects include sleepiness, dizziness, tiredness, and nausea.[3] Other side effects may include suicide, psychosis, angioedema, and anxiety.[3] Use in pregnancy may harm the baby.[3] How it works is unclear; however, may related to synaptic vesicle protein 2A.[4] It is chemically similar to levetiracetam.[4]

Brivaracetam was approved for medical use in the United States and Europe in 2016.[3][2] In the United Kingdom 4 weeks of medications costs the NHS about £130 as of 2021.[5] This amount in the United States is about 1,200 USD.[6]

References[edit]

  1. ^ a b "Briviact- brivaracetam tablet, film coated Briviact- brivaracetam solution Briviact- brivaracetam injection, suspension". DailyMed. 15 May 2018. Archived from the original on 21 March 2021. Retrieved 25 January 2019.
  2. ^ a b c d "Briviact (in Italy: Nubriveo)". Archived from the original on 29 December 2021. Retrieved 11 January 2022.
  3. ^ a b c d e "DailyMed - BRIVIACT- brivaracetam tablet, film coated BRIVIACT- brivaracetam solution BRIVIACT- brivaracetam injection, suspension". dailymed.nlm.nih.gov. Archived from the original on 21 March 2021. Retrieved 11 January 2022.
  4. ^ a b c "Brivaracetam Monograph for Professionals". Drugs.com. Archived from the original on 26 July 2021. Retrieved 11 January 2022.
  5. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 326. ISBN 978-0857114105.
  6. ^ "Briviact Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 11 January 2022.
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