Talk:Reverse triiodothyronine

References?

Does anyone have references, specifically on the fact (?) that rT3 does indeed bind to, but not activate the T3 receptor? I can find references that imply that rT3 is a competitive byproduct with T3 for T4 de-iodination by DIO1, but cannot find any specific reference to binding affinity to the T3-receptor - in fact, I have found a couple of articles that imply that rT3 is completely biologically inactive'. It is widely held within the 'alternative thyroid health community' that rT3 does indeed bind to T3 receptors and thus directly block T3 action, but unfortunately, this does not cut it when dealing with a doctor who wants to know why I want to run a (rather expensive) rT3 test (or, why I want to treat with Cytomel instead of Armour to "clear out" an rT3 dominant state, presumably by allowing the DIO1 enzyme to 'reset' - literature on this seems hard to come by as well.. —Preceding unsigned comment added by 216.9.143.94 (talk) 18:19, 4 August 2008 (UTC)

How about this site: http://endo.endojournals.org/cgi/content/abstract/110/6/2052 —Preceding unsigned comment added by 141.153.49.178 (talk) 21:02, 20 December 2008 (UTC)

Clinical information: Please note that there is a great deal of specific clinical information including successful, time-tested protocols, for addressing rT3 dominance. Cytomel (synthetic T3) is conceptually the right idea, but timing of administration turns out to be an important factor. Using time-released T3 from a compounding pharmacy turns out, clinically, to be essential to success. Cytomel, on the other hand, is an immediate release formulation.

Complete protocols and background information can be found by reading the free eManual at http://www.wilsonstemperaturesyndrome.com/eManual. The Wilson's Temperature Syndrome site will also provide links to reliable compounding pharmacies and healthcare providers with experience in addressing conditions caused by reverse T3 dominance. --Ecobiotics (talk) 21:03, 26 February 2010 (UTC)

Colleagues and "friends of rT3": I have written a long - encyclopedic, in fact - article on reverse T3. My reviewing editor has instructed me to post it on this page to solicit editorial comments. Of course, I hope it will be accepted for use, at least in some form. Please review it on my sandbox (http://en.wikipedia.org/wiki/User:Njmcdaniel/sandbox) - "Unsigned," you'll find your answer there, to the extent it exists - and would someone tell me the next steps for submission?

Thanks much! Njmcdaniel (talk) 00:27, 8 July 2013 (UTC) (Alan)