Talk:Guaifenesin

helps with withdrawal??

I hope this anecdote isn't seen as out of place on the talk page, but I felt it couldn't hurt.

I recently took Mucinex DM tablets which contain guaifenesin and dextromethorphan to help recover from a lingering cough, which was exacerbated by my habitual smoking. My usual cravings for nicotine seem to disappear, and come back if I miss a dose of Mucinex. I have since read that the drug can increase nausea when combined with nicotine, but I have experienced no nausea. I have found absolutely no information about guaifenesin affecting nicotine withdrawal. Is it possible that I am experiencing some sort of placebo effect, even without any expectation of this side effect? —Preceding unsigned comment added by 66.195.207.241 (talk) 00:18, 10 March 2009 (UTC)

This isnt really the place to talk about this but dextromethorphan is a nicotonic antagonist so that might have to do with why it effects your cigarette withdrawel.

abuse vs. use

Resolved

Please DO NOT use the word abuse in the context of psychoacitve drugs. Abuse is defined differently by many people, use however is a neutral term. I find the use of the word abuse to be very naive. I happen to be a regular drug user but I have not let it affect my social life, my work, or school.

what? its only "use" if you created the drug yourself,i dont think you did, did you?it's referred to as "abuse" when you are abusing products intended for medical purposes.any use of the product outside of medical reasons is illegal. you are "abusing" your government-given priveledges to get high. —Preceding unsigned comment added by 66.205.103.10 (talk) 03:49, 19 June 2008 (UTC)

General

Did guaifenesin originate in Asia or is it based on a substance in the Asian ecosystem or pharmacopia? The name seems to suggest guai feng or something like that. knoodelhed 16:52, 14 December 2006 (UTC)

Not really. AFAIK, the name "guaifenesin" comes from the guaiacol ring in the guaifenesin molecule (you can see it on the left in the structural image), and "-fenesin" is due to its similarity to mephenesin, a compound which was discovered earlier. (Caveat lector: WP has a policy against original research. You've been warned :) Fvasconcellos 17:41, 14 December 2006 (UTC)

This is a question about the etymology of the word and also the history of the drug. Neither has yet been addressed in this article. --Una Smith (talk) 18:26, 23 December 2007 (UTC)

Use in Fertility Treatment

Resolved

How about adding a section on the use of Guaifenesin with fertility treatments. I know that my wife's doctor recommended that she take it since the other medications would dry out her vaginal mucosas, then the guaifenesin would help with lubrication, as well as promote a better environment for the sperms. Is anybody up to researching this a little better, and adding this section? It would be a great help. 71.16.238.125 (talk) 03:38, 29 November 2007 (UTC)

My doctor recommended this as well. Here's an article on it: http://www.babyhopes.com/articles/robitussin.html. I am sure there are other, more authoritative sources as well. -Corinne —Preceding unsigned comment added by 216.231.48.104 (talk) 06:57, 6 December 2007 (UTC)

Guaifenesin is very widely used to improve cervical mucus. The support for its use is almost entirely anecdotal. There is just one article on this topic in the medical literature, involving a very small population and lacking controls. I have added a section on use by women. --Una Smith (talk) 18:12, 23 December 2007 (UTC)

I used Benylin for my cough and it has definately changed the cervical mucus! |Thought I had a problem down there till I looked up the guaifenesin. Sorry to say it like that but thats how I can describe it. So yes in theory it could help! —Preceding unsigned comment added by 217.34.245.93 (talk) 21:02, 11 February 2008 (UTC) —Preceding unsigned comment added by 66.205.103.10 (talk)

Solubility

Is this substance soluble in alcohol, water or any other solvent? There's no information about it's route of absorption in the digestive tract. 97.82.247.200 19:24, 8 September 2007 (UTC)

Guaifenesin is soluble in water (5 g/100 cm³) and freely soluble in alcohol. I believe its pharmacokinetics are not well known, hence the conspicuous lack of information in the article :) Fvasconcellos (t·c) 21:44, 8 September 2007 (UTC)

"Guafenisin"

Resolved

I don't know how to do redirects, but I think somebody should redirect searches for "guafenisin" to this article. I think that's a VERY likely misspelling. I was a spelling bee champ, and I still misspelled guafenesin that way. --63.25.26.104 23:03, 28 September 2007 (UTC)

I've added that as a redirect. See Wikipedia:Redirect on how to do redirects. -- Ash Lux ^{(talk | contribs)} 18:24, 11 October 2007 (UTC)

Citation for its effectiveness???

Under "Treatment of asthma" the article states:

"Guaifenesin is effective in the treatment of the thickened bronchial mucosa characteristic of asthma. It works by drawing water into the bronchi."

Hartnady (talk) 20:02, 4 August 2016 (UTC) Edit: The above statement no longer appears in the main article.

Under "Use by singers" the article states:

"Singers sometimes refer to guaifenesin as the "wonder drug", for its ability to promote secondary mucosal secretion in the respiratory system."

But no citation is given for either of these claims. (In the second quote it is the unquestioning reference to guaifenesin's supposed "ability to promote secondary mucosal secretion in the respiratory system" that concerns me.)

I have never been able to find any reliable verification of the effectiveness of guaifenesin as an expectorant. Furthermore, many pharmacists whom I have asked about it have told me that they are not aware of any confirmation, either, that guaifenesin has any of these claimed properties.

SO: Unless unbiased clinical trials are soon cited in the article showing guaifenesin has these claimed properties, I intend to remove these claims as unverified.Daqu 18:31, 19 October 2007 (UTC)

Hm. It is a matter of fact that guaifenesin is the sole active ingredient in many cough syrups labeled "expectorant". Daqu, you are welcome to add "fact" tags to the article. Have you tried searching the medical literature? --Una Smith (talk) 18:26, 23 December 2007 (UTC)

Questionable Citation Re: FDA

"Moreover, because of concerns about illegal recreational drugs, the American FDA has forced manufacturers of ephedrine to add guaifenesin to over the counter weight loss medications."

This statement cites the referenced Docket response by David Riddle, but the cited work never makes this claim. The cited work is a statement by a producer of an athsma treatment requesting that the guaifenesin/ephedrine combination not be promoted to schedule II as it is a long-standing effective combination. Nowhere therein is the claim made that the inclusion of guaifenesin is being forced upon them. Quite the contrary, in fact. Suggest deletion of this entire passage. —Preceding unsigned comment added by 64.81.160.131 (talk) 01:47, 4 November 2007 (UTC)

UK

Lemsip Max All-in-One (a cold/flu remedy) contains guaifenesin, and is available OTC. I won't edit as I'm unsure of the conventions for drug articles, but it might be useful for a more experienced editor. At the moment nowhere outside N. Am. is even mentioned, which is not great. 86.135.7.222 (talk) 00:51, 4 July 2008 (UTC)

Side effects?

Resolved

Are there any side effects or negative symptoms that could occur while using Mucinex? —Preceding unsigned comment added by 83.251.183.150 (talk) 01:29, 30 July 2008 (UTC)

This article discusses known side effects of guaifenesin. --Una Smith (talk) 16:07, 29 October 2008 (UTC)

Veterinary uses, pharmacology

Good source on Google Books here. --Una Smith (talk) 03:22, 9 September 2008 (UTC)

Why so many 'Citation Needed' tags?

An occasional c.n. tag is not unusual in a technical article, but a proliferation of them in a scatter-gun like fashion, many after fairly matter-of-fact statements, normally indicates that someone has taken issue with the subject matter. It's a distraction, and in my experience detracts from the article. I normally see this kind of thing more on hotly-contested topics like religion, natural remedies and so forth - is it because this compound is generally perceived as quackery? It's unusual to see an active ingredient found in so many over-the-counter preparations being 'attacked' in this fashion. I have no opinion either way, having come to this page 'cold' to check out a bottle of Veno's expectorant on my shelf! Blitterbug (talk) 00:14, 24 March 2009 (UTC)

dextromethorphan is a very questionable remedy

The vague unsourced assertion here of benefits should probably be removed. —Preceding unsigned comment added by Ocdcntx (talk • contribs) 20:15, 24 January 2010 (UTC)

Hey guys, this

" Feng J, Zhang Z,Li W, Shen X, Song W, Yang C, Chang F, Longmate J, Marek C, St. Amand, RP, Krontiris T, Shively JE, Sommer SS. Missense Mutations in the MEFV Gene are Associated with Fibromyalgia Syndrome and Correlate with Elevated IL-1 beta Plasma Levels. PLosOne Dec. 2009; Vol 4; issue 12 e8480. " caused a glitch making the page extra wide so I deleted it. Fix it proper and thanks —Preceding unsigned comment added by 24.250.242.46 (talk) 23:45, 19 September 2010 (UTC)

Merge or redirect of Meltus

Is there any reason that Meltus should not redirect to this article? Toddst1 (talk) 20:40, 31 October 2011 (UTC)

As far as I can tell the term "meltus" has no connection to guaifenesin. The article that was originally created at meltus was mere vandalism, so I think the redirect should be deleted. -- Ed (Edgar181) 20:53, 31 October 2011 (UTC)

Mucinex

To my understanding Mucinex was the only drug to make an extended release (12 hour) form of the drug. I wasn't sure if that would be information that would be worth putting in the article. http://www.mucinex.com/professional/docs/pdfs/2.61_Adult%20Dosing%20Card.pdf — Preceding unsigned comment added by 108.88.109.27 (talk) 04:09, 10 August 2012 (UTC)

In order for the article to say that Mucinex has the only such form of the drug, we would need a secondary reliable source which says so. The official Mucinex sight is a primary source and is not a suitable reference for such a claim. -- JTSchreiber (talk) 04:39, 16 August 2012 (UTC)

Mucinex is not (or is no longer) the only form of extended release guaifenesin tablets available in the United States. I have personally purchased (October, 2013) at Walgreen Drugs, their store brand of "Mucus Relief" 12-hour, extended-release 600mg guaifenesin tablets.AnClarTex 18:57, 3 October 2013 (UTC)

Wal-Mart also has an own-brand (Equate) version. The tablets are imprinted with "Mxeunic" in a very similar typeface to that of Mucinex tablets. While there's a trademark acknowledgement on the box, there's no disclaimer that it's not made by Reckitt Benckiser (compare Equate Tussin DM, which has such a disclaimer about the owners of the Robitussin trademark). It also states "PRODUCT OF ENGLAND". NIH's DailyMed page for the Equate 1200 mg 28-pack [1] mentions RB under "Ingredients and Appearance/Establishment" as "Business Operations: Manufacture". That record cites NDA021282, whose Supplement 48's letter (July 2017) refers to "authorized generic versions of the approved Mucinex products and proposes the following: Add new packaging site / Remove dye / Change debossing".

That leads me to believe that this product is made by RB. I think NIH should qualify as a reliable secondary source, but I don't know whether I'm reading their information correctly.—Dah31 (talk) 22:29, 29 August 2019 (UTC)

The FDA's Orange Book lists (search for "guaifenesin") other approved Applicant Holders for extended-release guaifenesin, so it looks to me like some generic brands are made by RB and some are made by other manufacturers.—Dah31 (talk) 22:37, 29 August 2019 (UTC)

The plug for Mucinex in the intro violates WP:NOTADVERTISING in my opinion. It was added in this 07:00, 8 June 2019‎ edit by a new editor with only 12 edits over two days in June 2019, and no edits since, and who was possibly unfamiliar with WP policies and guidelines. I support its removal and restoring the lead section to one that is promo-free. Mucinex already appears in the Medical use section, no need to give it prominence in the opening sentence over all the other brands. 5Q5|^✉ 16:40, 27 November 2019 (UTC)

Please link to "Mucokinetics"

This article needs to link to the one on Mucokinetics. — Preceding unsigned comment added by 209.6.116.14 (talk) 22:30, 16 February 2013 (UTC)

Half-Life

I'm not sure how to edit on here correctly, but the half life is incorrect. It is 1 hour, not 24hours. The reference for the 24hour half-life refers to a 600mg time release form. Can someone correct this? Here is another reference for pharmacology of the drug that shows its half-life is 1hr. http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=47694

Good catch. I note that the source used is an abstract from a meeting which was likely not peer reviewed. In it they claim 1-5 hours for half-life after taking the extended release form. Let me root around for a secondary source that is a little more appropriate.Desoto10 (talk) 03:02, 13 July 2013 (UTC)

I am not sure if the quoted source is specifying plasma half-or effect hals-life. I changed the number in the table to at least agree with the ref.Desoto10 (talk) 03:30, 13 July 2013 (UTC)

Mucinex redirect?

Currently Mucinex redirects to Guaifenesin, however there are now additional formulations of Mucinex that include additional active ingredients. For example, Mucinex Fast-MAX Multi-symptom Severe Congestion & Cough also contains Dextromethorphan HBr and Phenylephrine HCl. Although each of these have their own Wikipedia page, there is no linkage to all three active ingredients via a page for the Mucinex range of products, forcing interested users to search for each individual ingredient separately.

I (re)added a redirect for Musinex to this page. This should suffice until a complete product page is created for it (like the page for Robitussin), since this is the primary ingredient in all of the Musinex products. — Loadmaster (talk) 15:56, 27 May 2016 (UTC)

skeptical anytime I see a reference to Cochrane

I'm skeptical anytime I see anything sourced from "Cochrane Collaboration" — Preceding unsigned comment added by 67.180.134.108 (talk) 06:10, 15 February 2015 (UTC)

Why does Mucostop re-direct here?

As far as I can tell from reading the ingredients, Mucostop doesn't contain Guaifenesin. Minerva9 (talk) 21:44, 15 February 2017 (UTC)

was done by User:PotatoBot during one of its runs. Jytdog (talk) 22:55, 15 February 2017 (UTC)

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Pronunciation

How is guaifenesin pronounced? I've heard both gwai-uh-fe-ne'-sen and gwai-uh-fen'-uh-sen (with the accent on ne and fen, respectively). Does anyone know of a RS for this? — Loadmaster (talk) 19:04, 2 April 2018 (UTC)

Seems like an advertisement for Mucinex

The brand is mentioned at least 7 times on this page and I only see one mention of a competing brand. It's also mentioned in the very first sentence, and appears in the Google search result snippet. Guaifenesin has been on the market for ages longer than Mucinex has been around, and there are many other brands. I'm not comfortable editing this one myself, but I hope someone can please fix this for credibility reasons. Looks very much like a corporate branding edit.

Note: I now see this was also mentioned at the very end of the Mucinex section above as a violation of advertising rules. Let's fix this. 174.102.134.232 (talk) 12:14, 5 January 2020 (UTC)

It's just the way US pharmacology works, and this article is written from a primarily American perspective. As a Brit I've never heard of Mucinex, but I'm sure it's a big brand in the Land of the Free. Even US medical professionals tend to refer to drugs by brand rather than generic name. --Ef80 (talk) 17:06, 27 September 2022 (UTC)

I only see three mentions of Mucinex in the article...? I don't think it's over-represented really. Guaifenesin is an over the counter med in the Land of the Free :) so I do think three mentions is unnecessary. I may take a crack at it. cheers. anastrophe, an editor he is. 19:27, 27 September 2022 (UTC)

Unverified claim.

In the first paragraph "A 2014 study found that guaifenesin did not have significant impact on sputum production or clearance in upper respiratory infections." Which study? Jim.00236a6 (talk) 14:56, 29 August 2023 (UTC)

@Jim.00236a6

Done. Please review! Tosha Langue (talk) 15:28, 29 August 2023 (UTC)