Sapio Sciences

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Sapio Sciences LLC
Founded2004; 20 years ago (2004)
Headquarters
Baltimore, MD
,
United States
ProductsLaboratory Management software
Websitewww.sapiosciences.com

Sapio Sciences is a technology company that develops software to support drug research and discovery processes. Founded by Kevin Cramer, Sapio Sciences has developed software products for laboratory operations, particularly in biotechnology and chemistry.[1]

History[edit]

Sapio Sciences was founded in 2004 to develop software tools to address the growing genotyping need for tools to assist in analyzing genetics data, particularly in relation to Genome Wide Association Studies. Sapio's Exemplar Analytics software grew to incorporate over 50 different algorithms. Sapio was subsequently approached by customers to develop a Laboratory Information Management System (LIMS). This led to the development of Exemplar LIMS in June 2007 by Kevin Cramer with several extensions since then.[2][3] The company targets highly regulated environments such as part 11, GLP and CLIA laboratories.[4] Kevin Cramer has a background in Information Systems from York College, PA. He has co-authored multiple papers in Nature Genetics, applying statistical and machine learning methodologies to genetic data interpretation.[5]

In 2013, Sapio Sciences launched Web Client 1.0. Sapio was then the first to integrate a full-featured, web-based Electronic Lab Notebook with its LIMS (Laboratory Information Management System) built together on a single software platform in 2017.[6]

In 2020 the company launched a new Sapio Platform that extended its core platform with additional modules for data analysis and knowledge extraction.[7][3] The Sapio Platform was iterated on to add templated modules for different life sciences applications, including biotechnology research, next-generation sequencing (NGS), bioanalysis, etc.[8][9][10][11][12]

In the summer of 2023, NatureMetrics selected Sapio LIMS to enable environmental DNA sequencing.[13] In 2023, Oxford Biomedica selected Sapio ELN for its cell and gene therapy research and development business.[14] In 2023, Immunebridge announced it had selected the Sapio Electronic Lab Notebook to modernize its enterprise data management for its work on NK cell-based immunotherapies.[15] In November 2023, Sapio Sciences became the first company to introduce an AI-Chat Scientific Assistant integrated directly into an Electronic Laboratory Notebook (ELN), called ELaiN (Electronic Lab Artificially Intelligent Notebook).[16][17]

Operations[edit]

Sapio Sciences is focused on expediting drug discovery processes through its unified lab platform that has built-in science applications and data management tools, including web client, data designer, and a workflow engine, among other tools. Kevin Cramer is the founder and CEO.[18]

Products[edit]

Exemplar was introduced in 2007 as a LIMS and electronic laboratory notebook product.[19] The software was subsequently expanded to perform additional tasks.[20]

Workflow and data tracking features were introduced in 2008 to allow the software to be used for Scientific Data Management (SDMS).[21] Statistics have also be implemented to perform detailed analysis of scientific data within the same environment.[22]

Biomarker discovery[edit]

Sapio extended its software with features for biomarker discovery including features for managing clinical study data, treatment groups data, subject data, sample data and assay data from diverse assays such as Immunohistochemistry, Western Blot, PCR, etc. Basic data mining and statistical analysis tools are included for tasks such as data normalization, logistic regression, ANOVA and genetic algorithms.

Molecular diagnostics[edit]

Sapio introduced the Exemplar[23] Dx LIMS product for molecular diagnostic companies that is optimised to handle diagnostic test request and results. In addition to sample management and protocol tracking, it emphasises kit and instrument integration with Dx platforms such as Qiagen and Beckman Coulter.[24] Physicians can be presented a web interface for test ordering, or test requests can be imported using the HL7 format. Assay data is then managed in Exemplar and the Dx companies custom algorithms can be implemented to analyze the data and produce the diagnostic report automatically. This report, once electronically signed off, is then delivered via the web, secure fax, HL7 or secure email to the requesting physician.[25]

References[edit]

  1. ^ Godswill, Ntsomboh Ntsefong (2015). Innovative and Efficient Laboratory Management. Xlibris US. pp. 62–65. ISBN 9781503564367.
  2. ^ Strebig, Neil (2019-01-16). "York, Pa., surges with success built on much more than bars and restaurants". York Daily Record. Retrieved 2024-04-19.
  3. ^ a b Thurow, Kerstin; Junginger, Steffen (2022). Devices and Systems for Laboratory Automation. Wiley (published August 3, 2022). pp. 462–466. ISBN 9783527348329.{{cite book}}: CS1 maint: date and year (link)
  4. ^ "ExonHit Bets on Sapio LIMS". Bio-IT World. Retrieved 2012-10-26.
  5. ^ Hanlon, Rebecca (2021-09-21). "Entrepreneur with two tech companies downtown asks, 'Why not York?'". The Founder Beat. Retrieved 2024-04-19.
  6. ^ "Exemplar LIMS Web Client 1.0 | Scientific Computing World". www.scientific-computing.com. Retrieved 2024-04-19.
  7. ^ D. Hanton, Scott; F. Conway, John; Rivero, Ralph; Baumes, Laurent (2020-12-10). "High Throughput Experimentation Drives Better Outcomes". Lab Manager. Retrieved 2024-04-19.
  8. ^ "Norwich COVID-19 testing initiative pilot: evaluating the feasibility of asymptomatic testing on a university campus". academic.oup.com. 2020-10-30. Retrieved 2024-04-19.
  9. ^ Wallace, Andrew J. (2016-08-12). "New challenges for BRCA testing: a view from the diagnostic laboratory". European Journal of Human Genetics. 24 (1): S10–S18. doi:10.1038/ejhg.2016.94. ISSN 1476-5438. PMC 5141576.
  10. ^ Bergeron-Sawitzke, Julie; Gold, Bert; Olsh, Adam; Schlotterbeck, Sarah; Lemon, Kendal; Visvanathan, Kala; Allikmets, Rando; Dean, Michael (2009-03-04). "Multilocus analysis of age-related macular degeneration". European Journal of Human Genetics. 17 (9): 1190–1199. doi:10.1038/ejhg.2009.23. ISSN 1476-5438. PMC 2729805. PMID 19259132.
  11. ^ Brusie, Chaunie (2019-04-20). "Sapio Sciences Launches Expanded Laboratory Informatics Platform". Clinical Lab Products. Retrieved 2024-04-19.
  12. ^ "Sapio Sciences announces full GxP validation of its unified laboratory informatics platform and suite of solutions". ITDigest. 2024-01-12. Retrieved 2024-04-19.
  13. ^ "NatureMetrics selects Sapio Science's platform for DNA monitoring". NS Healthcare. 2023-07-06. Retrieved 2024-04-19.
  14. ^ "Oxford Biomedica Implements Sapio Sciences' Electronic Laboratory Notebook". Contract Pharma. Retrieved 2024-04-19.
  15. ^ "ImmuneBridge Chooses Sapio Sciences Electronic Lab Notebook to Modernize and Scale Enterprise Data Management". BioSpace. Retrieved 2024-04-19.
  16. ^ "Sapio Sciences – A comprehensive AI assistant for scientists". califesciences.org. Retrieved 2024-04-19.
  17. ^ "The Digital Lab. "What it is and How we get there"". bio-itworldexpo.com. 2020-10-01. Retrieved 2024-04-19.
  18. ^ Haber, Gary (2015-09-14). "Sapio Sciences, a software company, moves into former York Dispatch building". York Daily Record. Retrieved 2024-04-19.
  19. ^ "Compare Nautilus LIMS vs. Sapio LIMS in 2024". slashdot.org. Retrieved 2024-04-19.
  20. ^ Lukoseviciute, M.; Holzhauser, S.; Pappa, E.; Mandal, T.; Dalianis, T.; Kostopoulou, O. N. (2023). "Efficacy of combined targeted therapy with PI3K and CDK4/6 or PARP and WEE1 inhibitors in neuroblastoma cell lines". Oncology Reports. 50 (3): 166. doi:10.3892/or.2023.8603. PMC 10394730. PMID 37477144.
  21. ^ "Sapio Sciences Exemplar LIMS 4.0". Scientificcomputing.com. 2010-06-16. Archived from the original on 2012-03-11. Retrieved 2012-10-26.
  22. ^ "Genseq wählt Sapio LIMS für erstklassige Next-Generation-Sequenzierungsdienste". www.pharma-zeitung.de. Retrieved 2024-04-19.
  23. ^ Hu, Hai; Mural, Richard J.; Liebman, Michael N. (2008). Biomedical Informatics in Translational Research. Artech House. ISBN 978-1-59693-039-1.
  24. ^ "Sapio Granted Full GxP Validation of Lab Informatics Platform". Contract Pharma. Retrieved 2024-04-19.
  25. ^ "Sapio Sciences gibt die vollständige GxP-Validierung seiner einheitlichen Laborinformatik-Plattform und seiner Lösungspalette bekannt". www.pharma-zeitung.de. Retrieved 2024-04-19.
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