Draft:Svetlana Minina

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  • Comment: Not enough independent, significant coverage. WikiOriginal-9 (talk) 04:25, 6 November 2023 (UTC)
  • Comment: Please look at the notability criteria in WP:N and WP:NACADEMIC. Currently there is no proof here of notability. If you continue to submit without massive changes it will probably be rejected without the option to resubmit.
    In addition, none of the claims are supported by independent sources. Don't use her work, you must use others for a significant number of these. Ldm1954 (talk) 19:54, 20 October 2023 (UTC)

Svetlana Minina (Moscow) is a Soviet and Russian biophysicist whose work has pushed the boundaries of neuroscience, physics, and mathematics. Spanning over 50 publications.[1][2], her discoveries have been instrumental in the development of quantum biology and have acted as a catalyst for an array of further explorations[3][4].

Early Life and Education[edit]

Minina was born in Moscow in 1950. She graduated from the Department of Higher Nervous Activity at Moscow State University School of Biology[5] and then went on to obtain her PhD[6] at the Institute for information transmission problems of the Russian Academy of Sciences. As an academic, she defended her thesis "Influence of Cyсlic Nucleotides on Membrane Potential and Impulse Activity of Neurons," in 1978[7]. She defended her PhD, "Function of a Neuron, Role of cAMP," in 1992[8][9]. There she met fellow biophysicist Efim Liberman, who became her husband and close collaborator[10][11].

Scientific career[edit]

Svetlana Vladimirovna Minina, in collaboration with her husband Efim Liberman and their associates, made significant strides in bridging biology, information science, and quantum physics. Their work is well-regarded for advancing the idea that biomolecular processes can be understood as informational processes. This perspective, illustrated in their 1979 work, aligns them with early thinkers like Turing, Polanyi, and Rosen, who were instrumental in framing biology as an informational science.[12]

Quantum Molecular Computer Model of the Brain[edit]

Together with Dr. Liberman and Dr. Shklovsky-Kordi, Dr. Minina developed the idea that the brain operates as a quantum molecular computer (QMC)[13][14]. This pioneering concept suggests that the brain is essentially a network of intraneuronal computers in which information processing occurs at the molecular level.[15] [16] [17]Specifically, they posited that a stochastic molecular computer (MCC) controls each living cell, operating with molecule-words (DNA, RNA, proteins) according to the program recorded in DNA and RNA[3]. Computational operations are implemented by molecular operators acting as enzymes. An MCC is present in every living cell, including neurons, and can be involved in solving tasks for the entire organism.

An MCC is present in every living cell, including neurons, and can be involved in solving tasks for the entire organism[18]. The framework crafted by Liberman and Minina is reflected in recent theoretical work by Becerra et al., where synthetic biology is used as a method to program bacterial behavior using artificial neural networks. This echoes Minina and Liberman's foundational insight into molecular computing within cells, extending their ideas into new domains of synthetic biology and artificial intelligence[18].

The Neuronal Quantum Computing Mechanism[edit]

To uncover how neurons could functionally operate as quantum computers, Drs. Minina and Efim Liberman focused on cyclic AMP (cAMP), a signaling molecule known to rapidly affect membrane electrical activity when applied extracellularly[19]. In a groundbreaking discovery, it was demonstrated for the first time that directly injecting cAMP inside neurons could also elicit fast electrical responses[20]. The unusual energetics and rapid kinetics of cAMP’s effects provided critical evidence that quantum processes could be involved in this intraneuronal signaling mechanism[20].

It was hypothesized that this intracellular effect was due to cAMP interacting with the neuron's cytoskeleton, composed of microtubule tubulin networks linked by Microtubule Associated Proteins (MAPs) like MAP2[21]. It was proposed that the neuronal cytoskeleton acts as the calculating medium for the quantum molecular computer, with MAP2 mediating signaling between cAMP and microtubules[22]. Additionally, it was theorized that ion channels generate inputs to the cytoskeletal computer in the form of hypersonic signals that propagate via phonons across the quantum coherent microtubule lattice[22].

This quantum cytoskeletal computing model was further supported when experiments showed rapid cytoskeletal changes as neurons solved complex motor tasks[23]. Microtubule assembly patterns were also found to differ between neuronal types[24]. As described, “the construction of the calculating part of the cytoskeleton...is different in each neuron” reflecting their specialized functions[22].

Implications for Theories of Consciousness[edit]

The exploration of microtubules as pivotal information processors aiding cognition laid groundwork for quantum theories of consciousness[13]. These insights informed models like Penrose and Hameroff's Orch OR theory, which posits consciousness may arise from quantum computations occurring in microtubules inside brain neurons[25].

More specifically, the quantum cytoskeletal computing model suggests the idea that microtubules process information via quantum effects. The observation that microtubules reorganize rapidly as neurons address complex tasks provides evidence of these structures' direct participation in cognition[23].

Concepts such as the extreme quantum regulator were also introduced, potentially accounting for features of awareness like a subjective inner "point of view"[26].

By extending our understanding of how microtubules may enable quantum information processing in the brain, this investigative work propelled forward theories regarding the physics underlying consciousness[27]

Quantum Biology Principles[edit]

Dr. Minina and Dr. Efim Liberman developed key concepts using quantum physics and information theory to explain how living systems operate[13]. They introduced terms like the quantum molecular regulator to describe efficient molecular computing within cells[26].

They theorized that cells utilize quantum effects for enhanced decision-making, information processing, and control. The idea of a quantum molecular regulator suggests that cells, due to their quantum structure, have an inner "point of view" akin to free will[26]. Dr. Minina also helped formulate the principle of the minimum price of action, stating that quantum molecular computers operate with minimal energy, close to the Planck constant h[24], showcasing quantum computing's energy efficiency compared to classical systems.

It was further suggested that cells employ quantum computing for decision-making on control tasks defined by mathematical physics equations[13]. Quantum effects like wave interference, entanglement, and tunneling were theorized to help cells solve complex problems quickly and accurately, surpassing classical computers.

Additionally, the work by Fingelkurts and Fingelkurts[28] acknowledges the pioneering quantum molecular computer model of the neuron by Liberman, Minina, and colleagues. By referencing this foundational work, the paper underscores the significance of quantum biology principles in understanding the genetic basis of neurocognitive capacities and performance.

Implications for Neurodegenerative Disease[edit]

Research on cAMP signaling and the MAP2-microtubule cytoskeletal network provided essential insights into neurodegenerative diseases like Alzheimer's[22]. It was demonstrated that dysfunctional cytoskeletal proteins like MAP2 contribute to Alzheimer's pathogenesis by disrupting neuronal information processing and intracellular signaling[29]. The work revealed how perturbed cAMP-MAP2-microtubule signaling could lead to cognitive deficits and neurodegeneration in Alzheimer’s. By furthering understanding of the neuronal cytoskeleton's role in cognition, this research enabled new therapeutic opportunities for Alzheimer’s focused on restoring microtubule function and stability. These pioneering contributions advanced knowledge of how cytoskeletal dysregulation causes neurological disorders.

Family[edit]

Svetlana Vladimirovna Minina is married to Efim Arsentievich Liberman, a Soviet and Russian biophysicist and physiologist, and winner of the USSR State Prize (1975). They had six children, including daughters Anna (b. 1981) and Maria (b. 1978), and sons Daniil (b. 1982), David (b. 1984), and Gavriil[30]. David and Daniil produced the TV show Mult Lichnosti on Channel One Russia, which aired from 2009 to 2013. They are entrepreneurs and founders of the venture capital fund Brothers Ventures and Frank.Money in the United States.

Academic journals and publications[edit]

  1. Hameroff, Stuart. (2012). “ULTIMATE COMPUTING - Quantum Consciousness. Stuart Hameroff.”[25]
  2. Liberman, E. A.; Minina, S. V.; Shklovsky-Kordi, N. E.; Conrad, Michael (1982-01-01). "Microinjection of cyclic nucleotides provides evidence for a diffusional mechanism of intraneuronal control". Biosystems.[21]
  3. Liberman, E. A.; Minina, S. V.; Myakotina, O. L.; Shklovsky-Kordi, N. E.; Conrad, Michael (1985-07-08). "Neuron generator potentials evoked by intracellular injection of cyclic nucleotides and mechanical distension". Brain Research.[19]
  4. Liberman, E. A.; Minina, S. V.; Shklovsky-Kordi, N. E. (1989-01-01). "Quantum molecular computer model of the neuron and a pathway to the union of the sciences". Biosystems.[13]
  5. Liberman, E. A.; Minina, S. V. (1995-01-01). "Molecular quantum computer of neuron". Biosystems. Proceeding of the 1993 Meeting of International Society for Molecular Electronics and Biocomputing.[24]
  6. Liberman, E. A.; Minina, S. V. (1996-01-01). "Cell molecular computers and biological information as the foundation of nature's laws". Biosystems.[31]
  7. Liberman, E. A.; Minina, S. V.; Moshkov, D. A.; Santalova, I. M.; Chistopolskiy, I. A.; Shklovski-Kordi, N. E. (2008-04-01). "Experimental testing of the role of cytoskeleton in the solution by neurons of problems facing the brain".[23]
  8. Liberman, E.A.; Minina, S.V.; Myakotina O.L., Mamikonova T.A., Tsofina L.M. and Shklovski- Kordi N.E. (1988). "Unusual biochemistry of changes in neuron membrane permeability evoked by cAMP". FEBS Letters.[20]
  9. Minina, Svetlana V.; Shklovski-Kordi, Nikita E. (2022-07-01). "Neuron quantum computers and a way to unification of science: A compendium of Efim Liberman's scientific work". Biosystems.[3]
  10. Minina, S. V. “Variability of the response types induced by cyclic 3’,5’-adenosine monophosphate into identified molluscan neurons.” Biofizika 31, no. 5 (1986): 919–21.
  11. Minina, S. V., O. L. Myakotina, V. B. Avdonin, and E. A. Liberman. “Mechanical Influence and CAMP Injection Evoke the Same Reaction of Neuron Ionic Channels.” FEBS Letters 289, no. 2 (September 9, 1991): 224–26.[32]
  12. Minina, S. V., and E. A. Liberman. “Input and output channels of quantum biocomputers”. Biofizika 35, no. 1 (1990): 132–36.[22]
  13. Liberman, E. A; Minina, S. V; Shklovski-Kordi, N. E (1998-04-01). "Biological information and laws of nature". Biosystems. 46 (1): 103–106. doi:10.1016/S0303-2647(97)00086-5. ISSN 0303-2647.[33]
  14. Liberman, E. A.; Minina, S. V.; Shklovsky-Kordi, N. E.; Conrad, Michael (1981-01-01). Hypothesis about the role of random connections between the brain nerve cells. Biofizika 26, 153-157.

Books[edit]

  1. Electricity and Control of a Living Cell (together with S.V.Minina and N.E. Shklovsky-Kordi).— M.: Znaniye, 1978.[34]
  2. The Brain as a System of Quantum Computers and the Way to Unification of the Sciences (together with S.V.Minina and N.E. Shklovsky-Kordi). — M.: AN USSR, Institute for Information Transmission Problems, 1987.[35]

References[edit]

  1. ^ "Efim Liberman's family tree". efim.liberman.net. Retrieved 2023-10-25.
  2. ^ "Research Gate".
  3. ^ a b c Svetlana V. Minina a, Nikita E. Shklovskiy-Kordi (July 2022). "Neuron quantum computers and a way to unification of science: A compendium of Efim Liberman's scientific work". Biosystems. 217: 104684. Bibcode:2022BiSys.21704684M. doi:10.1016/j.biosystems.2022.104684. ISSN 0303-2647. PMID 35443201. S2CID 248233084.
  4. ^ Hofkirchner, Wolfgang (1999). The Quest for a Unified Theory of Information: Proceedings of the Second International Conference on the Foundations of Information Science. Psychology Press. ISBN 978-90-5700-531-2.
  5. ^ "Efim Liberman's family tree". efim.liberman.net. Retrieved 2023-10-25.
  6. ^ Heller, Nathan (2022-07-25). "Is Selling Shares in Yourself the Way of the Future?". The New Yorker. ISSN 0028-792X. Retrieved 2023-10-25.
  7. ^ "Светлана Минина — биография, книги, отзывы, цитаты". www.livelib.ru. Retrieved 2023-10-25.
  8. ^ "Efim Liberman's family tree". efim.liberman.net. Retrieved 2023-10-25.
  9. ^ "Светлана Минина — биография, книги, отзывы, цитаты". www.livelib.ru. Retrieved 2023-10-25.
  10. ^ "Светлана Минина — биография, книги, отзывы, цитаты". www.livelib.ru. Retrieved 2023-10-25.
  11. ^ Shklovskiy-Kordi, Nikita E.; Igamberdiev, Abir U. (2022-06-01). "Natural computation and its limits: Efim Liberman at the dawn of a new science". Biosystems. 215–216: 104653. Bibcode:2022BiSys.21504653S. doi:10.1016/j.biosystems.2022.104653. ISSN 0303-2647. PMID 35240243. S2CID 247185689.
  12. ^ Fields C, Levin M. (Nov 2021). "Metabolic limits on classical information processing by biological cells". Biosystems. 209. arXiv:2103.17061. Bibcode:2021BiSys.20904513F. doi:10.1016/j.biosystems.2021.104513. PMID 34450208. S2CID 232427774.
  13. ^ a b c d e E.A. Liberman, S.V. Minina, N.E. Shklovsky-Kordi (1989). "Quantum molecular computer model of the neuron and a pathway to the union of the sciences". Biosystems. 22 (2): 135–154. Bibcode:1989BiSys..22..135L. doi:10.1016/0303-2647(89)90042-7. ISSN 0303-2647. PMID 2541828.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  14. ^ "Светлана Минина — биография, книги, отзывы, цитаты". www.livelib.ru. Retrieved 2023-10-25.
  15. ^ Hofkirchner, Wolfgang (1999). The Quest for a Unified Theory of Information: Proceedings of the Second International Conference on the Foundations of Information Science. Psychology Press. ISBN 978-90-5700-531-2.
  16. ^ "On Shared Minds and Human Stocks: The Liberman Brothers". ZORA ZINE. Retrieved 2023-10-25.
  17. ^ "Либерман Ефим Арсентьевич". iitp.ru. Retrieved 2023-10-25.
  18. ^ a b Becerra, A. Gargantilla; Gutiérrez, M.; Lahoz-Beltra, R. (2022-03-01). "Computing within bacteria: Programming of bacterial behavior by means of a plasmid encoding a perceptron neural network". Biosystems. 213: 104608. Bibcode:2022BiSys.21304608B. doi:10.1016/j.biosystems.2022.104608. ISSN 0303-2647. PMID 35063580. S2CID 246166275.
  19. ^ a b Liberman, E. A.; Minina, S. V.; Mjakotina, O. L.; Shklovsky-Kordy, N. E.; Conrad, Michael (8 July 1985). "Neuron generator potentials evoked by intracellular injection of cyclic nucleotides and mechanical distension". Brain Research. 338 (1): 33–44. doi:10.1016/0006-8993(85)90245-8. ISSN 0006-8993. PMID 2992684. S2CID 46156067.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  20. ^ a b c Efim A. Liberman, Svetlana V. Minina, Olga L. Myakotina, Tatyana A. Mamikonova, Lilia M. Tsofina, Nikita E. Shklovskl-Kordi (August 29, 1988). "Unusual biochemistry of changes in neuron membrane permeability evoked by cAMP". FEBS Letters. 236 (2): 445–449. doi:10.1016/0014-5793(88)80074-7. ISSN 0014-5793. PMID 2842193. S2CID 13333070.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  21. ^ a b E.A. Liberman, S.V. Minina, N.E. Shklovsky-Kordy, Michael Conrad (1982). "Microinjection of cyclic nucleotides provides evidence for a diffusional mechanism of intraneuronal control". Biosystems. 15 (2): 127–132. Bibcode:1982BiSys..15..127L. doi:10.1016/0303-2647(82)90026-0. ISSN 0303-2647. PMID 6286008.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  22. ^ a b c d e S. V. Minina, E. A, Liberman (January 1990). "Input and output channels of quantum biocomputers". Biofizika. 35 (1): 132–6. PMID 1693290.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  23. ^ a b c E. A. Liberman, S. V. Minina, D. A. Moshkov, I. M. Santalova, I. A. Chistopolskiy & N. E. Shklovski-Kordi (6 May 2008). "Experimental testing of the role of cytoskeleton in the solution by neurons of problems facing the brain". Biochemistry (Moscow). 73 (4): 479–482. doi:10.1134/S0006297908040147. ISSN 1608-3040. PMID 18457579. S2CID 38196582.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  24. ^ a b c E.A. Liberman, S.V. Minina (1995). "Molecular quantum computer of neuron". Biosystems. 35 (2–3): 203–207. Bibcode:1995BiSys..35..203L. doi:10.1016/0303-2647(94)01515-9. ISSN 0303-2647. PMID 7488717.
  25. ^ a b Hameroff, Stuart. "Ultimate computing". {{cite journal}}: Cite journal requires |journal= (help)
  26. ^ a b c Liberman, E.A. (1983). Extremal molecular quantum regulator (28 ed.). Biofizika. pp. 183–185, 197–201.
  27. ^ "Libermans Co". Libermans Co. Retrieved 2023-10-25.
  28. ^ Fingelkurts, Alexander A.; Fingelkurts, Andrew A. (January 2022). "Quantitative Electroencephalogram (qEEG) as a Natural and Non-Invasive Window into Living Brain and Mind in the Functional Continuum of Healthy and Pathological Conditions". Applied Sciences. 12 (19): 9560. doi:10.3390/app12199560. ISSN 2076-3417.
  29. ^ Jin Zhang, Xiao-Ping Dong (September 1, 2012). "Dysfunction of Microtubule-Associated Proteins of MAP2/Tau Family in Prion Disease". Prion. 6 (4): 334–38. doi:10.4161/pri.20677. PMC 3609059. PMID 22874672.
  30. ^ "Клан Либерманов: как одна семья прошла путь от «Первого» до Snapchat". Журнал РБК. Retrieved 2023-10-25.
  31. ^ E.A. Liberman, S.V. Minina (1996). "Cell molecular computers and biological information as the foundation of nature's laws". Biosystems. 38 (2–3): 173–177. Bibcode:1996BiSys..38..173L. doi:10.1016/0303-2647(95)01588-4. ISSN 0303-2647. PMID 8734525.
  32. ^ Svetlana V. Minina, Olga L. Myakotina, Vladimir B. Avdonin, Efim A. Liberman (September 9, 1991). "Mechanical influence and cAMP injection evoke the same reaction of neuron ionic channels". FEBS Letters. 289 (2): 224–26. doi:10.1016/0014-5793(91)81075-J. PMID 1655525. S2CID 46337710.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  33. ^ E.A Liberman, S.V Minina, N.E Shklovski-Kordi (April 1998). "Biological information and laws of nature". Biosystems. 46 (1–2): 103–106. Bibcode:1998BiSys..46..103L. doi:10.1016/S0303-2647(97)00086-5. ISSN 0303-2647. PMID 9648680.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  34. ^ S.V.Minina, N.E. Shklovsky-Kordi, E. A. Liberman (1978). Electricity and Control of a Living Cell (In Russian: Электричество и управление живой клетки) (in Russian). Moscow: Znanie.{{cite book}}: CS1 maint: multiple names: authors list (link)
  35. ^ S.V.Minina, N.E. Shklovsky-Kordi, E. A. Liberman (1987). The Brain as a System of Quantum Computers and the Way to Unification of the Sciences (In Russian: Мозг как система квантовых компьютеров и путь к объединению наук). Institute for Information Transmission Problems.{{cite book}}: CS1 maint: multiple names: authors list (link)
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