BRAT1

BRAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IFI
Identifiers
Aliases	BRAT1, BAAT1, C7orf27, RMFSL, BRCA1 associated ATM activator 1, NEDCAS
External IDs	OMIM: 614506 MGI: 1891679 HomoloGene: 16776 GeneCards: BRAT1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	2,555,694 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	140,705,134 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right uterine tube; ; canal of the cervix; ; anterior pituitary; ; body of stomach; ; left uterine tube; ; right lobe of thyroid gland; ; skin of abdomen; ; left lobe of thyroid gland; ; gastric mucosa;
	Top expressed in
	interventricular septum; ; spermatocyte; ; ascending aorta; ; endocardial cushion; ; external carotid artery; ; proximal tubule; ; internal carotid artery; ; visual cortex; ; molar; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; membrane; nucleus; nucleoplasm;
Biological process	mitochondrion localization; response to ionizing radiation; cell growth; positive regulation of protein phosphorylation; cell population proliferation; cell migration; glucose metabolic process; cellular response to DNA damage stimulus; apoptotic process; positive regulation of cell growth;
	Sources:Amigo / QuickGO
Orthologs
	221927
	231841
	ENSG00000106009
	ENSMUSG00000000148
	Q6PJG6
	Q8C3R1
	NM_152743; NM_001350626; NM_001350627
	NM_001276287; NM_172724; NM_181066
	NP_689956; NP_001337555; NP_001337556
	NP_001263216; NP_851411
	Wikidata
View/Edit Human	View/Edit Mouse

BRCA1-associated ATM activator 1 is a protein in humans that is encoded by the BRAT1 gene.^[5]

Function[edit]

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.^[5]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106009 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000148 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: BRCA1-associated ATM activator 1".

External links[edit]

Human BRAT1 genome location and BRAT1 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human BRCA1-associated ATM activator

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106009 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000148 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: BRCA1-associated ATM activator 1".

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